Citation: Li Jun, Xu Xiaoshi, Teng Haida, Chen Yu, Mei Zhinan, Yang Guangzhong. Chemical Constituents from Hypericum Erectum Thunb[J]. Chinese Journal of Organic Chemistry, ;2019, 39(12): 3583-3587. doi: 10.6023/cjoc201904066 shu

Chemical Constituents from Hypericum Erectum Thunb

Li Jun ^a,† ,
Xu Xiaoshi ^a,† ,
Teng Haida ^b ,
Chen Yu ^b ,
Mei Zhinan ^a,, ,
Yang Guangzhong ^a,,

a.
School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074
b.
College of Chemistry and Materials Sciences, South-Central University for Nationalities, Wuhan 430074

Corresponding author: Mei Zhinan, meizhinan@163.com Yang Guangzhong, yanggz888@126.com

^†

Received Date: 26 April 2019
Revised Date: 17 June 2019
Available Online: 17 December 2019
Fund Project: the National Major New Drugs Innovation and Development 2017ZX09301060Project supported by the National Major New Drugs Innovation and Development (No. 2017ZX09301060) and the Special Fund for Basic Scientific Research of Central Colleges, South-Central University for Nationalities (No. CZP18004)the Special Fund for Basic Scientific Research of Central Colleges, South-Central University for Nationalities CZP18004

Figures(3)

The chemical constituents of Hypericum erectum Thunb were isolated and purified by solvent extraction method, the normal and reverse phase silica gel column chromatography and semi-preparative high performance liquid chromatography. Their structures were elucidated by their physicochemical property and extensive analysis of spectroscopic data. Three new compounds which belong to α-pyranone, flavonoid and aliphatic alcohol respectively, together with 15 known compounds, were isolated from the chloroform extract of H. erectum. Inflammatory cell model was constructed by lipopolysaccharide (LPS)-stimulated RAW264.7 cell line. NO production inhibitory effects of all tested compounds were measured by Griess method. Hyperiflavone (2), isocudraniaxan-thone B (5) and 2-deprenylrheediaxanthone B (6) exhibited moderate NO production inhibitory activities with the IC₅₀ values of 16.24, 9.86 and 12.90 μmol·L^-1, respectively.
- Hypericum Linn,
- Hypericum erectum Thunb,
- xanthone,
- anti-inflammatory activity
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