Citation: Wang Maorui, Wu Yuzheng, Yao Jian, Deng Li, Pan Yingming, Huang Kebin, Tang Haitao. Triethylamine Promoted the C-C Bond Cleavage of α-Halo Ketones: α-Acetoxyaryl Ketone Synthesis[J]. Chinese Journal of Organic Chemistry, ;2019, 39(11): 3223-3229. doi: 10.6023/cjoc201904051 shu

Triethylamine Promoted the C-C Bond Cleavage of α-Halo Ketones: α-Acetoxyaryl Ketone Synthesis

State Key Laboratory for Chemistry and Molecular Engineering of Medicinal Resources, School of Chemistry and Pharmaceutical Sciences, Guangxi Normal University, Guilin, Guangxi 541004

Corresponding author: Huang Kebin, kbhuang@mailbox.gxnu.edu.cn Tang Haitao, httang@gxnu.edu.cn
Received Date: 22 April 2019
Revised Date: 7 June 2019
Available Online: 2 November 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21362002), and the Bagui Scholar Program of Guangxi Province of China (No. 2016A13)the Bagui Scholar Program of Guangxi Province of China 2016A13the National Natural Science Foundation of China 21362002

Figures(4)

The cleavage of C-C bonds is a key method for synthesis of useful intermediates. A novel amine-promoted C-C bond cleavage of α-halo ketones was reported. Oxidant-free and metal-free conditions are the striking features of the protocol. In this simple method, a variety of α-acetoxyaryl ketone compounds were prepared from commercially available α-halo ketones in good to excellent yields.
- cleavage of C-C bonds,
- α-halo ketones,
- oxidant-free and metal-free,
- α-acetoxyaryl ketone
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