Citation: Hu Xiaoyu, Yu Haifeng, Wang Wenju, Jiang Siao, Liu Qi, He Jie. Synthesis of 3-Ethanoyl/Aroylacetylindoles in Water[J]. Chinese Journal of Organic Chemistry, ;2019, 39(11): 3183-3189. doi: 10.6023/cjoc201904002 shu

Synthesis of 3-Ethanoyl/Aroylacetylindoles in Water

College of Chemistry, Baicheng Normal University, Baicheng, Jilin 137000

Corresponding author: Yu Haifeng, yuhf68105@sina.com Wang Wenju, wangwj3309@126.com
Received Date: 3 April 2019
Revised Date: 18 June 2019
Available Online: 9 November 2019
Fund Project: Project supported by the Foundation of Science and Technology Research Projects of the 13th Five-Year Plan of Jilin Provincial Department of Education (No. 2016037)the Foundation of Science and Technology Research Projects of the 13th Five-Year Plan of Jilin Provincial Department of Education 2016037

Figures(2)

4-Dodecylbenzenesulfonic acid (DBSA) catalyzed hydrolysis reaction of β-ethylthio-β-indolyl-α, β-unsaturated ketones (1) in water to yield 3-ethanoyl/aroylacetylindoles (2) was studied. It showed that the hydrolysis of 1 in water smoothly occurred in the presence of 10 mol% DBSA in reflux water, and 2 was obtained in excellent yield.
- aqueous reaction,
- hydrolysis reaction,
- 3-acetoacetylindole,
- β-ethylthio-β-indolyl-α, β-unsaturated ketone
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