Citation: Wang Zhao, Hao Lingyun, Zhang Xiaojuan, Sheng Ruilong. Advances of "Click" Reaction Approach in Glycopolypeptide Synthesis[J]. Chinese Journal of Organic Chemistry, ;2019, 39(9): 2379-2391. doi: 10.6023/cjoc201903038 shu

Advances of "Click" Reaction Approach in Glycopolypeptide Synthesis

a.
School of Material Engineering, Jinling Institute of Technology, Nanjing 211169, China
b.
CQM-Centro de Química da Madeira, Universidade da Madeira, Campus da Penteada, 9000-390 Funchal, Portugal
c.
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

Corresponding author: Sheng Ruilong, ruilong.sheng@staff.uma.pt
Received Date: 21 March 2019
Revised Date: 19 April 2019
Available Online: 6 September 2019
Fund Project: the Reforço do Investimento em Equipamentos e Infraestruturas Científicas na RAM M1420-01-0145-FEDER-000008the Fundação para a Ciência e a Tecnologia PEst-OE/QUI/ UI0674/2019the National Natural Science Foundation of China (No. 21372251), the Research Initiation Fund for High-level Talents of Jinling University of Science and Technology (No. jit-b-201828), the Fundação para a Ciência e a Tecnologia (No. PEst-OE/QUI/ UI0674/2019), the Reforço do Investimento em Equipamentos e Infraestruturas Científicas na RAM (No. M1420-01-0145-FEDER-000008), and the Sub Topic 2017-ISG-003 of Agência Regional para o Desenvolvimento da Investigação Tecnologia e Inovação (No. M1420-01-0145-FEDER-000005)the National Natural Science Foundation of China 21372251the Research Initiation Fund for High-level Talents of Jinling University of Science and Technology jit-b-201828

Figures(15)

Synthetic glycopolypeptides, as analogues of natural glycoproteins, are an emerging class of bioinspired polymers with excellent biocompatibility. They can mimic the structure and functions of natural glycoproteins, and show great potential for biological applications, such as biomolecular recognition, drug/gene delivery, cell adhesion and targeting, as well as cell culture and tissue engineering. Nevertheless, the efficient and lab/pilot scale preparation of well-defined and tunable glycopolypeptides with complex polymer structures, has been a challenging field until now. The fast development of "Click" chemistry/reaction offers versatile and powerful tools for the synthesis of glycopolypeptides. The state of arts for the development of new "Click" synthetic strategies and methods in the preparation of glycopolypeptides, mainly including post-polymerization glycosylation of synthetic polypeptides and ring-opening polymerization of glycosylated N-carboxyanhydride (glyco-NCA) is reviewed. The pros and cons of current developments for the synthesis of glycopolypeptide analogues and their future perspectives are also stated and discussed.
- glycopolypeptide,
- "Click" reaction,
- post-polymerization glycosylation,
- ring-opening polymerization
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沈阳化工大学材料科学与工程学院沈阳 110142

Advances of "Click" Reaction Approach in Glycopolypeptide Synthesis

南开大学师唯/华北电力大学（保定）刘景维：二维配位聚合物中有序的亲锂冠醚位点用于无枝晶锂沉积

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