Citation: Sun Wanwan, Mao Yujian, Jiang Jing, Yu Jing, Chen Lingyun, Hu Yanwei, Zhang Shilei. Synthesis of 12H-Chromeno[2, 3-b]quinolin-12-one and 6H-Chromeno[4, 3-b]quinolin-6-one from Anthranil[J]. Chinese Journal of Organic Chemistry, ;2019, 39(9): 2525-2533. doi: 10.6023/cjoc201903034 shu

Synthesis of 12H-Chromeno[2, 3-b]quinolin-12-one and 6H-Chromeno[4, 3-b]quinolin-6-one from Anthranil

Jiangsu Key Laboratory of Neuropsychiatric Diseases and College of Pharmaceutical Sciences, Soochow University, Suzhou 215123

Corresponding author: Hu Yanwei, huyanwei@suda.edu.cn Zhang Shilei, zhangshilei@suda.edu.cn
Received Date: 19 March 2019
Revised Date: 19 April 2019
Available Online: 6 September 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21202112), the Ph.D. Programs Foundation of Ministry of Education (No. 20123201120019) and the Priority Academic Program Development of Jiangsu Higher Education Institutionsthe National Natural Science Foundation of China 21202112the Ph.D. Programs Foundation of Ministry of Education 20123201120019

Figures(3)

Two heterocyclic compounds 12H-chromeno[2, 3-b]quinolin-12-one and 6H-chromeno[4, 3-b]quinolin-6-one could be synthesized by the reaction of anthranil with 4-hydroxycoumarin under high temperature conditions. The reaction is a thermo-promoted transformation, without the assistance of catalysts or additives, and without the generation of toxic wastes. This one-step reaction is superior to other reported methods for the preparation of such heterocycles.
- high-temperature reaction,
- anthranil,
- 4-hydroxycoumarin,
- synthesis of heterocycles
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