Citation: Ahmad Muhammad Siddique, Zhu Yamin, Guo Yunlong, Zhang Saisai, Shen Zengming. Copper-Catalyzed Aerobic Oxidation Strategy: A Concise Route to Isatin[J]. Chinese Journal of Organic Chemistry, ;2019, 39(11): 3244-3249. doi: 10.6023/cjoc201903024 shu

Copper-Catalyzed Aerobic Oxidation Strategy: A Concise Route to Isatin

School of Chemistry and Chemical Engineering, Shanghai Jiao Tong University, Shanghai 200240

Corresponding author: Shen Zengming, shenzengming@sjtu.edu.cn
Received Date: 14 March 2019
Revised Date: 28 May 2019
Available Online: 12 November 2019
Fund Project: Project supported by the National Natural Sciences Foundation of China (No. 21672144)the National Natural Sciences Foundation of China 21672144

Figures(4)

A copper-catalyzed decarbonylation cyclization to form isatins using oxygen as terminal oxidant is developed. This complementary way offers a new protocol for the synthesis of isatins through C(sp³)—H bond functionalization in Cu/O₂/Co system. This system shows good reactivity and compatibility. Both electron-rich and electron-deficient functional groups can be tolerated. A postulated mechanism is proposed based on mechanistic studies and previous reports.
- Cu catalyst,
- C—H bond activation,
- isatin,
- decarbonylation,
- oxygen
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