Citation: Chang Yongxin, Li Bai, Guo Miao, Cai Yonghong, Xu Kuoxi. A Novel Logic Gate Fluorescent Sensor for the Sequential Detection of Cd²⁺ and Pyrophosphate Anion and Application in Cell Imaging[J]. Chinese Journal of Organic Chemistry, ;2019, 39(9): 2485-2491. doi: 10.6023/cjoc201903010 shu

A Novel Logic Gate Fluorescent Sensor for the Sequential Detection of Cd²⁺ and Pyrophosphate Anion and Application in Cell Imaging

Chang Yongxin ^a ,
Li Bai ^a ,
Guo Miao ^b ,
Cai Yonghong ^a,, ,
Xu Kuoxi ^a,,

a.
Engineering Laboratory for Flame Retardant and Functional Materials of Henan Province, Institute of Functional Organic Molecular Engineering, College of Chemistry and Chemical Engineering, Henan University, Kaifeng 475004
b.
Institute of Nanomaterials Engineering Research Center, Henan University, Kaifeng 475004

Corresponding author: Cai Yonghong, caiyonghong@henu.edu.cn Xu Kuoxi, xukx@henu.edu.cn
Received Date: 5 March 2019
Revised Date: 18 March 2019
Available Online: 11 September 2019
Fund Project: Project supported by the National Natural Science Foundation of China (No. U1404207)the National Natural Science Foundation of China U1404207

Figures(11)

A novel fluorescent sensor L based on 8-hydroxyquinoline (8-HQ) has been designed and synthesized. The sensor L displayed excellent sensitivity specific toward Cd²⁺ and pyrophosphate anion (PPi), respectively. The fluorescence emission peak at 537 nm was quenched when Cd²⁺ was added to the DMSO/H₂O (V/V=1/1, 0.01 mol/L, Hepes-HCl buffer, pH=7.20) solution of sensor L and the detection limit was as low as 5.87×10^-8 mol/L. The 1:1 stoichiometry was verified by Job's plot and mass spectrum, and the association constant was obtained to be 4.37×10⁴ L/mol. The further study found that the L-Cd²⁺ system has high selectivity for detection of PPi by ligand replacement method and L could be used as a logic gate fluorescence sensor. In addition, the sensor L was employed for imaging the Cd²⁺ and PPi in living cells.
- 8-hydroxyquinoline,
- fluorescent sensor,
- sequential detection,
- cell imaging
1. [1]
  Duan, F.; Liu, G.; Liu, P.; Fan, C.; Pu, S. Tetrahedron 2016, 72, 3213. doi: 10.1016/j.tet.2016.04.043
2. [2]
  Meng, X.; Cao, D.; Hu, Z.; Han, X.; Li, Z.; Liang, D.; Ma, W. Tetrahedron Lett. 2018, 59, 4299. doi: 10.1016/j.tetlet.2018.10.048
3. [3]
  Arumugaperumal, R.; Srinivasadesikan, V.; Lin, M.-C.; Shel-laiah, M.; Shukla, T.; Lin, H.-C. RSC Adv. 2016, 6, 106631. doi: 10.1039/C6RA24472F
4. [4]
  Lv, Y.; Wu, L.; Shen, W.; Wang, J.; Xuan, G.; Sun, X. J. Porphyrins Phthalocyanines 2015, 19, 769. doi: 10.1142/S1088424615500510
5. [5]
  Wang, C. Y.; Fu, J. X.; Yao, K.; Chang, Y. X.; Yang, L.; Xu. K, X. ChemistrySelect 2018, 3, 2805. doi: 10.1002/slct.201800158
6. [6]
  Wang, P.; Liu, X. Y.; Fu, J. X.; Chang, Y. X.; Yan, L.; Xu, K. X. Can. J. Chem. 2018, 96, 835. doi: 10.1139/cjc-2017-0741
7. [7]
  Zhang, L.; Hu, W.; Yu, L.; Wang, Y. Chem. Commun. 2015, 51, 4298. doi: 10.1039/C4CC09769F
8. [8]
  Sandra, A.; Rutledge, P.; Todd, M. J. Eur. J. Inorg. Chem. 2012, 34, 5611.
9. [9]
  Liu, H, Y.; Tan, Y.; Dai, Q, Z.; Liang, H, D.; Song, J.; Qu, J, L.; Wong, W, Y. Dyes Pigm. 2018, 158, 312.
10. [10]
  Liu, S.; Wang, Y. M.; Han, J. J. Photochem. Photobiol. C 2017, 32, 78. doi: 10.1016/j.jphotochemrev.2017.06.002
11. [11]
  Guo, Y. X.; Wang, L.; Zhuo, J. Z.; Xu, B.; Li, X.; Zhang, J. Y.; Zhang, Z. Q.; Chi, H. J.; Dong, Y.; Lu, G. H. Tetrahedron Lett. 2017, 58, 3951. doi: 10.1016/j.tetlet.2017.08.078
12. [12]
  Joseph, W. N.; Hyunjung, L.; Lee, H, S.; Reibenspies, G, H.; Hancock, R, D. Inorg. Chem. 2014, 53, 9014. doi: 10.1021/ic5008632
13. [13]
  Wang, W.; Wei, J.; Liu, H.; Liu, Q.; Gao, Y. Tetrahedron Lett. 2017, 58, 1025. doi: 10.1016/j.tetlet.2017.01.010
14. [14]
  Luo, Y.; Tang, D.; Zhu, W.; Xu, Y.; Qian, X. J. Mater. Chem. C 2015, 3, 8485. doi: 10.1039/C5TC01249J
15. [15]
  Silva, A. P.; Nimal, G. H. Q.; Gunnlaugsson, T.; Allen, J. M.; Huxley, C. P. Chem. Rev. 1997, 97, 1515. doi: 10.1021/cr960386p
16. [16]
  Dong, Z. M.; Wang, W.; Qin, L. Y.; Feng, J.; Wang, J. N.; Wang, Y. J. Photochem. Photobiol. A:Chem. 2017, 335, 1. doi: 10.1016/j.jphotochem.2016.11.014
17. [17]
  Gogoi, A.; Samanta, S.; Das, G. Sens. Actuators, B 2014, 202, 788. doi: 10.1016/j.snb.2014.06.012
18. [18]
  Li, P.; Wang, Y. New J. Chem. 2017, 41, 4234. doi: 10.1039/C7NJ00913E
19. [19]
  Hao, J. N.; Yan, B. Chem. Commun. 2015, 51, 7737. doi: 10.1039/C5CC01430A
20. [20]
  Yao, K.; Fu, J. X.; Chang, Y. X.; Li, B.; Yang, L.; Xu, K. X. Spectrochim. Acta A 2018, 205, 410. doi: 10.1016/j.saa.2018.07.051
21. [21]
  Chang, Y. X.; Fu, J. X.; Yao, K.; Li, B.; Xu, K. X.; Pang, X. B. Dyes Pigm. 2019, 161, 331. doi: 10.1016/j.dyepig.2018.09.080
22. [22]
  Wang, P.; Fu, J. X.; Yao, K.; Chang, Y. X.; Xu, K. X. Sens. Actuators, B 2018, 273, 1070. doi: 10.1016/j.snb.2018.07.028
23. [23]
  Dai, Y. P.; Liu, X. Y.; Wang, P.; Fu, J. X.; Yao, K.; Xu, K. X. RSC Adv. 2016, 6, 99933. doi: 10.1039/C6RA23296E
1. [1]
  Siyi ZHONG , Xiaowen LIN , Jiaxin LIU , Ruyi WANG , Tao LIANG , Zhengfeng DENG , Ao ZHONG , Cuiping HAN . Targeting imaging and detection of ovarian cancer cells based on fluorescent magnetic carbon dots. Chinese Journal of Inorganic Chemistry, 2024, 40(8): 1483-1490. doi: 10.11862/CJIC.20240093
2. [2]
  Junmei FAN , Wei LIU , Ruitao ZHU , Chenxi QIN , Xiaoling LEI , Haotian WANG , Jiao WANG , Hongfei HAN . High sensitivity detection of baicalein by N, S co-doped carbon dots and their application in biofluids. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 2009-2020. doi: 10.11862/CJIC.20240120
3. [3]
  Qiaoqiao BAI , Anqi ZHOU , Xiaowei LI , Tang LIU , Song LIU . Construction of pressure-temperature dual-functional flexible sensors and applications in biomedicine. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2259-2274. doi: 10.11862/CJIC.20240128
4. [4]
  Xingchao Zhao , Xiaoming Li , Ming Liu , Zijin Zhao , Kaixuan Yang , Pengtian Liu , Haolan Zhang , Jintai Li , Xiaoling Ma , Qi Yao , Yanming Sun , Fujun Zhang . 倍增型全聚合物光电探测器及其在光电容积描记传感器上的应用. Acta Physico-Chimica Sinica, 2025, 41(1): 2311021-. doi: 10.3866/PKU.WHXB202311021
5. [5]
  Jiarong Feng , Yejie Duan , Chu Chu , Dezhen Xie , Qiu'e Cao , Peng Liu . Preparation and Application of a Streptomycin Molecularly Imprinted Electrochemical Sensor: A Suggested Comprehensive Analytical Chemical Experiment. University Chemistry, 2024, 39(8): 295-305. doi: 10.3866/PKU.DXHX202401016
6. [6]
  Meiqing Yang , Lu Wang , Haozi Lu , Yaocheng Yang , Song Liu . Recent Advances of Functional Nanomaterials for Screen-Printed Photoelectrochemical Biosensors. Acta Physico-Chimica Sinica, 2025, 41(2): 100018-. doi: 10.3866/PKU.WHXB202310046
7. [7]
  Jiakun BAI , Ting XU , Lu ZHANG , Jiang PENG , Yuqiang LI , Junhui JIA . A red-emitting fluorescent probe with a large Stokes shift for selective detection of hypochlorous acid. Chinese Journal of Inorganic Chemistry, 2024, 40(6): 1095-1104. doi: 10.11862/CJIC.20240002
8. [8]
  Jinlong YAN , Weina WU , Yuan WANG . A simple Schiff base probe for the fluorescent turn-on detection of hypochlorite and its biological imaging application. Chinese Journal of Inorganic Chemistry, 2024, 40(9): 1653-1660. doi: 10.11862/CJIC.20240154
9. [9]
  Qin Hou , Jiayi Hou , Aiju Shi , Xingliang Xu , Yuanhong Zhang , Yijing Li , Juying Hou , Yanfang Wang . Preparation of Cuprous Iodide Coordination Polymer and Fluorescent Detection of Nitrite: A Comprehensive Chemical Design Experiment. University Chemistry, 2024, 39(8): 221-229. doi: 10.3866/PKU.DXHX202312056
10. [10]
  Zhongxin YU , Wei SONG , Yang LIU , Yuxue DING , Fanhao MENG , Shuju WANG , Lixin YOU . Fluorescence sensing on chlortetracycline of a Zn-coordination polymer based on mixed ligands. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2415-2421. doi: 10.11862/CJIC.20240304
11. [11]
  Jun LUO , Baoshu LIU , Yunchang ZHANG , Bingkai WANG , Beibei GUO , Lan SHE , Tianheng CHEN . Europium(Ⅲ) metal-organic framework as a fluorescent probe for selectively and sensitively sensing Pb²⁺ in aqueous solution. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2438-2444. doi: 10.11862/CJIC.20240240
12. [12]
  Zhaoxin LI , Ruibo WEI , Min ZHANG , Zefeng WANG , Jing ZHENG , Jianbo LIU . Advancements in the construction of inorganic protocells and their cell mimic and bio-catalytical applications. Chinese Journal of Inorganic Chemistry, 2024, 40(12): 2286-2302. doi: 10.11862/CJIC.20240235
13. [13]
  Di Yang , Jiayi Wei , Hong Zhai , Xin Wang , Taiming Sun , Haole Song , Haiyan Wang . Rapid Detection of SARS-CoV-2 Using an Innovative “Magic Strip”. University Chemistry, 2024, 39(4): 373-381. doi: 10.3866/PKU.DXHX202312023
14. [14]
  Shuyu Liu , Xiaomin Sun , Bohan Song , Gaofeng Zeng , Bingbing Du , Chongshen Guo , Cong Wang , Lei Wang . Design and Fabrication of Phospholipid-Vesicle-based Artificial Cells towards Biomedical Applications. University Chemistry, 2024, 39(11): 182-188. doi: 10.12461/PKU.DXHX202404113
15. [15]
  Qilong Fang , Yiqi Li , Jiangyihui Sheng , Quan Yuan , Jie Tan . Magical Pesticide Residue Detection Test Strips: Aptamer-based Lateral Flow Test Strips for Organophosphorus Pesticide Detection. University Chemistry, 2024, 39(5): 80-89. doi: 10.3866/PKU.DXHX202310004
16. [16]
  Hong LI , Xiaoying DING , Cihang LIU , Jinghan ZHANG , Yanying RAO . Detection of iron and copper ions based on gold nanorod etching colorimetry. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 953-962. doi: 10.11862/CJIC.20230370
17. [17]
  Yang YANG , Pengcheng LI , Zhan SHU , Nengrong TU , Zonghua WANG . Plasmon-enhanced upconversion luminescence and application of molecular detection. Chinese Journal of Inorganic Chemistry, 2024, 40(5): 877-884. doi: 10.11862/CJIC.20230440
18. [18]
  Xiaowei TANG , Shiquan XIAO , Jingwen SUN , Yu ZHU , Xiaoting CHEN , Haiyan ZHANG . A zinc complex for the detection of anthrax biomarker. Chinese Journal of Inorganic Chemistry, 2024, 40(10): 1850-1860. doi: 10.11862/CJIC.20240173
19. [19]
  Min Gu , Huiwen Xiong , Liling Liu , Jilie Kong , Xueen Fang . Rapid Quantitative Detection of Procalcitonin by Microfluidics: An Instrumental Analytical Chemistry Experiment. University Chemistry, 2024, 39(4): 87-93. doi: 10.3866/PKU.DXHX202310120
20. [20]
  Tongyu Zheng , Teng Li , Xiaoyu Han , Yupei Chai , Kexin Zhao , Quan Liu , Xiaohui Ji . A DIY pH Detection Agent Using Persimmon Extract for Acid-Base Discoloration Popularization Experiment. University Chemistry, 2024, 39(5): 27-36. doi: 10.3866/PKU.DXHX202309107

Get Citation

PDF

XML

Metrics

PDF Downloads(5)
Abstract views(1512)
HTML views(148)

通讯作者: 陈斌, bchen63@163.com

1.
沈阳化工大学材料科学与工程学院沈阳 110142

A Novel Logic Gate Fluorescent Sensor for the Sequential Detection of Cd2+ and Pyrophosphate Anion and Application in Cell Imaging

Metrics

通讯作者: 陈斌, bchen63@163.com

A Novel Logic Gate Fluorescent Sensor for the Sequential Detection of Cd²⁺ and Pyrophosphate Anion and Application in Cell Imaging