Citation: Jiang Xiaolei, Hao Jiaqi, Zhou Guoqing, Hou Chengcheng, Hu Fangdong. Recent Advances in N-Phenoxyacetamides Directed C-H Bond Functionalizations[J]. Chinese Journal of Organic Chemistry, ;2019, 39(7): 1811-1830. doi: 10.6023/cjoc201902019 shu

Recent Advances in N-Phenoxyacetamides Directed C-H Bond Functionalizations

School of Chemistry and Chemical Engineering, Linyi University, Linyi 276000

Corresponding author: Hu Fangdong, hufangdong@lyu.edu.cn
Received Date: 19 February 2019
Revised Date: 14 March 2019
Available Online: 11 July 2019
Fund Project: the Higher Educational Science and Technology Program of Shandong Province J17KA099the Natural Science Foundation of Shandong Province ZR2018BB019the National Natural Science Foundation of China 21801109Project supported by the National Natural Science Foundation of China (No. 21801109), the Natural Science Foundation of Shandong Province (No. ZR2018BB019), and the Higher Educational Science and Technology Program of Shandong Province (No. J17KA099)

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The C-H bond activation has become one of the hot fields of organic chemistry in recent years due to its atom economy and step simplicity. In the conventional C-H bond activations, an equivalent amount of oxidants is usually added to regenerate the catalyst and allow the catalytic cycle proceed smoothly. N-Phenoxyacetamide, as a novel reaction substrate containing an oxidizing directing group, can effectively avoid the use of an equivalent external oxidants. Thus, the C-H activation could be conducted under redox neutral conditions. In this paper, the latest research progress of N-phenoxyacetamides in the field of organic synthesis, especially C-H bond activations is reviewed, and the mechanism of the reaction is discussed.
- N-phenoxyacetamides,
- internal oxidant,
- C-H bond activation,
- coupling partners
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