Citation: Ma Huifang, Li Wenbo, Ablajan Keyume. One-Pot Synthesis of Dihydro[1, 2, 4]triazolo[1, 5-a]pyrimidines and Dihydrobenzo[4, 5]imidazo[1, 2-a]pyrimidine Derivatives Catalyzed by Amberlyst-15[J]. Chinese Journal of Organic Chemistry, ;2019, 39(7): 1945-1952. doi: 10.6023/cjoc201901050 shu

One-Pot Synthesis of Dihydro[1, 2, 4]triazolo[1, 5-a]pyrimidines and Dihydrobenzo[4, 5]imidazo[1, 2-a]pyrimidine Derivatives Catalyzed by Amberlyst-15

Key Laboratory of Oil & Gas Fine Chemicals, Ministry of Education & Xinjiang Uyghur Autonomous Region, College of Chemistry and Chemical Engineering, Xinjiang University, Urumqi 830046

Corresponding author: Ablajan Keyume, ablajan209@hotmail.com
Received Date: 29 January 2019
Revised Date: 7 March 2019
Available Online: 9 July 2019
Fund Project: the National Science Foundation of China 21462041Project supported by the National Science Foundation of China (No. 21462041)

Figures(2)

Under the catalysis of solid acidic ion exchange resin Amberlyst-15, using ethanol as solvent, aromatic aldehyde, β-ketoester, and 3-amino-1, 2, 4-triazole or 2-aminobenzo as starting materials, a series of triazolo[1, 5-a]pyrimidine derivatives 5a~5m and dihydrobenzo[4,5]imidazo[1, 2-a]pyrimidines 6a~6g were synthesized by three-component one-pot reaction of imidazole derivatives. The method is simple and efficient, and has short reaction time, simple post-treatment and wide application range of the substrate. The catalyst can be recycled for 4 times without the significant decrease of catalytic activity. It conforms to the basic standard of green chemistry.
- dihydropyrimidine derivative,
- solid acidic ion exchange resin Amberlyst-15,
- one-pot reaction
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