Citation: Xie Zongbo, Li Hongxia, Liu Liansheng, Lan Jin, Hu Zhiyu, Le Zhanggao. Synthesis of Quinazolinone Derivatives Catalyzed by Alkaline Protease[J]. Chinese Journal of Organic Chemistry, ;2019, 39(9): 2632-2638. doi: 10.6023/cjoc201901037 shu

Synthesis of Quinazolinone Derivatives Catalyzed by Alkaline Protease

Department of Applied Chemistry, East China University of Technology, Nanchang 330013

Corresponding author: Xie Zongbo, zbxie@ecit.cn Le Zhanggao, zhgle@ecit.cn
Received Date: 24 January 2019
Revised Date: 27 March 2019
Available Online: 11 September 2019
Fund Project: the Science and Technology Foundation of the Jiangxi Education Department KJLD14050the Science and Technology Foundation of the Jiangxi Education Department GJJ150584the National Natural Science Foundation of China 21262002the Science and Technology Projects of Jiangxi 20161BCB24006the National Natural Science Foundation of China 21462001Project supported by the National Natural Science Foundation of China (Nos. 21462001, 21465002, 21262002), the Science and Technology Projects of Jiangxi (No. 20161BCB24006), and the Science and Technology Foundation of the Jiangxi Education Department (Nos. KJLD14050, GJJ150584)the National Natural Science Foundation of China 21465002

Figures(5)

Alkaline protease-catalyzed synthesis of quinazolinone derivatives was developed between β-keotester and o-aminobenzamide. Because ethanol is one kind of eco-friendly solvents, this method can reduce the impact of solvents on the environment. Alkaline protease as a biocatalyst has many advantages, e.g. high catalytic activity, environmentally friendly, wide variety of sources and simple operation. In addition, a variety of quinazolinone derivatives was obtained with good to excellent yields just using 2000 U alkaline protease as catalyst.
- quinazolinone derivatives,
- biocatalysis,
- alkaline protease,
- ethanol,
- promiscuity
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