Citation: Zhou Guangwei, Zhang Lizhu, Xue Yahan, Li Jiarong. Progress of N-Benzyl Removal[J]. Chinese Journal of Organic Chemistry, ;2019, 39(9): 2428-2442. doi: 10.6023/cjoc201901031 shu

Progress of N-Benzyl Removal

  • Corresponding author: Li Jiarong, jrli@bit.edu.cn
  • Received Date: 21 January 2019
    Revised Date: 13 March 2019
    Available Online: 16 September 2019

    Fund Project: Project supported by the 086 Special Fund

Figures(16)

  • N-Benzyl is a common protecting group for organic amines, owing to its convenient and efficient removal. It plays an important role in organic synthesis, especially in the research of drugs and natural products. In recent years, a large number of researchers have conducted extensive studies on N-benzyl deprotection, but the related work is scattered and lacks systematic review. Therefore, the progress of N-benzyl removal is systematically and comprehensively summarized from the aspects of reductive, oxidative and acid-base debenzylation.
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