Citation: Huang Chibao, Chen Hui, Li Fuqin, An Siya. Two-Photon Fluorescence Probes for Small Biomolecules Imaging[J]. Chinese Journal of Organic Chemistry, ;2019, 39(9): 2467-2484. doi: 10.6023/cjoc201901024 shu

Two-Photon Fluorescence Probes for Small Biomolecules Imaging

Huang Chibao ^a,b,, ,
Chen Hui ^a ,
Li Fuqin ^a ,
An Siya ^a

a.
Chemistry and Chemical Engineering College, Zunyi Normal University, Zunyi 563002
b.
College of Agricultural Science and Engineering, Shaoguan University, Shaoguan 512005

Corresponding author: Huang Chibao, huangchibao@163.com
Received Date: 17 January 2019
Revised Date: 24 February 2019
Available Online: 2 September 2019
Fund Project: the National Natural Science Foundation of China 21562050the Guizhou Province High-level Innovative Talents Training Project—Hundred Talents Program [2016]5683Project supported by the Guizhou Province High-level Innovative Talents Training Project—Hundred Talents Program (No. [2016]5683), the National Natural Science Foundation of China (No. 21562050), the Special Fund Project of the Construction of the Eighth Batch of Scientific and Technological Innovation Talent Team in Guizhou Province [No. (2015)4007], the Guizhou Science and Technology Fund Project (No. J[2015]2146), the Key Project of Education Department of Guizhou Province (No. KY[2014]296) and the Teaching Contents and Curriculum System Reform Project of Higher Education in Guizhou Province (No. KY [2014] JXGChcb)the Special Fund Project of the Construction of the Eighth Batch of Scientific and Technological Innovation Talent Team in Guizhou Province (2015)4007the Teaching Contents and Curriculum System Reform Project of Higher Education in Guizhou Province KY [2014] JXGChcbthe Key Project of Education Department of Guizhou Province KY[2014]296the Guizhou Science and Technology Fund Project J[2015]2146

Figures(21)

Small molecules (biological small molecules) in vivo are not only in a large number, involving inorganic small molecules, such as SO₂, H₂S, NO and CO, and more organic small molecules, such as monosaccharides, oligosaccharides, hormones, coenzymes, glycerol, stimulating factors, regulatory factors, Vitamins, etc., moreover, play an important role in pathology, physiology, and so on. Therefore, it is necessary to observe and monitor small molecules in vivo in real time, and the two-photon fluorescence probe is a necessary tool to achieve this goal. The advantages of two-photon fluorescence probe, such as fixed target (very small dot) excitation, high horizontal and vertical resolution, no photobleaching, no phototoxicity and deep imaging in tissues, and so on, demonstrate its unparalleled superiority. It can be used for dynamic 3D observation and monitoring of biological small molecules in cells or tissues. In this paper, CO, monosaccharide (glucose, β-galactosidase), SO₂, H₂S, NO, peroxy (sulfur) compounds, mercaptan/thiophenol, ¹O₂, formaldehyde, HNO, HclO, O₂^·- and ONOO^- two-photon fluorescence probes which have been developed in recent 5 years were reviewed. The sensing mechanisms of these two-photon fluorescence probes were systematically analyzed, and the development and prospect of two-photon fluorescence probes for small biomolecules are prospected.
- biological small molecule,
- fluorescent probe,
- sensing mechanism,
- fluorophore,
- receptor,
- two-photon bioimaging
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