Citation: Yan Shiqiang, Dong Daoqing, Xie Chunwen, Wang Wensheng, Wang Zuli. Synthesis of Bicyclic ortho-Aminocarbonitrile Derivatives Catalyzed by 1, 4-Diazabicyclo[2.2.2]octane[J]. Chinese Journal of Organic Chemistry, ;2019, 39(9): 2560-2566. doi: 10.6023/cjoc201901023 shu

Synthesis of Bicyclic ortho-Aminocarbonitrile Derivatives Catalyzed by 1, 4-Diazabicyclo[2.2.2]octane

a.
Qingdao Agricultural University, College of Chemistry and Pharmaceutical Sciences, Qingdao, 266109
b.
Shandong Dyne Marine Biopharmaceutical Co., Ltd., Weihai, 264300

Corresponding author: Wang Zuli, wangzulichem@163.com
Received Date: 17 January 2019
Revised Date: 20 April 2019
Available Online: 26 September 2019
Fund Project: the Special Projects for Independent Innovation and Achievement Transformation of Shandong Province 2015ZDXX0302A02Project supported by the National Natural Science Foundation of China (Nos. 81573340, 21402103, 21772107), the Special Projects for Independent Innovation and Achievement Transformation of Shandong Province (No. 2015ZDXX0302A02) and the Research Fund of Qingdao Agricultural University Highlevel Person (No. 631303)the Research Fund of Qingdao Agricultural University Highlevel Person 631303the National Natural Science Foundation of China 21772107the National Natural Science Foundation of China 21402103the National Natural Science Foundation of China 81573340

Figures(3)

One-pot three-component reactions catalyzed by 1, 4-diazabicyclo[2.2.2]octane (DABCO) for the synthesis of bicyclic ortho-aminocarbonitrile derivatives (21 examples, 68%~96%) have been developed. The reactions proceeded smoothly at room temperature and generated the corresponding products in short reaction time with high to excellent yields. Importantly, the desired products could be easily collected through simple filtration and washing with ethanol.
- 1, 4-diazabicyclo[2.2.2]octane (DABCO),
- multicomponent reaction,
- ortho-aminocarbonitrile derivatives,
- environmentally benign,
- ethanol
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