Citation: Ma Kaiqing, Ren Hubin, Wu Xiaoxiao, Chao Jianbin, Qin Xuemei. Total Synthesis of Racemic (±)-Parvistemonine A[J]. Chinese Journal of Organic Chemistry, ;2019, 39(7): 2094-2098. doi: 10.6023/cjoc201901010 shu

Total Synthesis of Racemic (±)-Parvistemonine A

Ma Kaiqing ^a,, ,
Ren Hubin ^a,b ,
Wu Xiaoxiao ^a ,
Chao Jianbin ^c ,
Qin Xuemei ^a

a.
Modern Research Center for Traditional Chinese Medicine, Shanxi University, Taiyuan 030006
b.
College of Chemistry and Chemical Engineering, Shanxi University, Taiyuan 030006
c.
Scientific Instrument Center, Shanxi University, Taiyuan 030006

Corresponding author: Ma Kaiqing, makaiqing@sxu.edu.cn
Received Date: 7 January 2019
Revised Date: 12 February 2019
Available Online: 8 July 2019
Fund Project: Project supported by the Shanxi Scholarship Council of China (No. 2015-020) and the Science and Technology Innovation Project of Shanxi Province (No. 2016115)the Shanxi Scholarship Council of China 2015-020the Science and Technology Innovation Project of Shanxi Province 2016115

Figures(3)

Parvistemonine A was isolated from Stemona parviflora. The total synthesis of racemic parvistemonine A was completed in 6 steps for the first time, employing compound 7 as the starting material. The synthetic strategy features a tandem Friedel-Crafts cyclization and lactonization, Vilsmeier-Haack and Julia-Kocienski olefination. This study laid the foundation for the synthesis of the parvistemonine A derivative and its biological activity research.
- natural product,
- stemona alkaloids,
- parvistemonine A,
- chemical synthesis
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