Citation: Fang Xiaolong, Duan Ning, Zhang Min, Zhang Chunyan, Liu Rui, Zhu Hongping. Homogeneous Catalytic Hydrogenation of Dimethyl Malonate into Methyl 3-Hydroxypropanoate[J]. Chinese Journal of Organic Chemistry, ;2019, 39(5): 1450-1455. doi: 10.6023/cjoc201812014 shu

Homogeneous Catalytic Hydrogenation of Dimethyl Malonate into Methyl 3-Hydroxypropanoate

Fang Xiaolong ^a,b,, ,
Duan Ning ^a ,
Zhang Min ^a ,
Zhang Chunyan ^b ,
Liu Rui ^b ,
Zhu Hongping ^b,,

a.
College of Chemistry and Materials Engineering, Chizhou University, Chizhou 247000
b.
State Key Laboratory of Physical Chemistry of Solid Surfaces, National Engineering Laboratory for Green Chemical Productions of Alcohols-Ethers-Esters, College of Chemistry and Chemical Engineering, Xiamen University, Xiamen 361005

Corresponding author: Fang Xiaolong, xlfang@stu.xmu.edu.cn Zhu Hongping, hpzhu@xmu.edu.cn
Received Date: 10 December 2018
Revised Date: 10 January 2019
Available Online: 31 May 2019
Fund Project: the National Natural Science Foundation for Young Scientists of China 21802010the Natural Science Foundation of Anhui Province 1808085QB48Project supported by the National Natural Science Foundation for Young Scientists of China (No. 21802010), the Natural Science Foundation of Anhui Province (No. 1808085QB48), and the Starting Grants for Young Teachers of Chizhou University (No. 2018YJRC001)the Starting Grants for Young Teachers of Chizhou University 2018YJRC001

Figures(4)

Ruthenium acetylacetonate and aminophosphine ligand were selected as the catalyst system and applied to the catalytic hydrogenation of dimethyl malonate into methyl 3-hydroxypropanoate. With the focus on the catalytic efficiency, the important factors with significant influences on the dimethyl malonate conversion and methyl 3-hydroxypropanoate selectivity were well discussed, including the structure and dosage of the ligand, temperature, reaction time, solvent, and so on. The results revealed that catalyst system of ruthenium acetylacetonate and o-(diphenylphosphino)aniline ligand could obtain significant catalytic results. Under the optimal reaction conditions, this catalyst system can also be applied to catalytic hydrogenation of some other esters with high efficiency.
- ruthenium acetylacetonate,
- o-(diphenylphosphino)aniline,
- dimethyl malonate,
- methyl 3-hydroxypropanoate
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