Citation: Mei Rongqing, Huang Guolei, Wang Bin, Bai Meng, Luo Youping, Chen Guangying, Zheng Caijuan. Two New Isocoumarins Isolated from a Mangrove-Derived Fungus Penicillium citrinum HL-5126[J]. Chinese Journal of Organic Chemistry, ;2019, 39(5): 1479-1482. doi: 10.6023/cjoc201812008 shu

Two New Isocoumarins Isolated from a Mangrove-Derived Fungus Penicillium citrinum HL-5126

Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158

Corresponding author: Zheng Caijuan, caijuan2002@163.com
Received Date: 5 December 2018
Revised Date: 29 December 2018
Available Online: 18 May 2019
Fund Project: the National Natural Science Foundation of China 21462015the National Natural Science Foundation of China 31760093the National Natural Science Foundation of Hainan Province 218MS045Project supported by the National Natural Science Foundation of China (Nos. 21462015, 31760093), the National Natural Science Foundation of Hainan Province (No. 218MS045), the Program for Innovative Research Team in University (No. IRT-16R19)the Program for Innovative Research Team in University IRT-16R19

Figures(3)

Two new isocoumarins derivatives, penicimarins J (1) and K (2), were isolated from the mangrove-derived fungus Penicillium citrinum HL-5126. Their structures were elucidated through extensive 1D NMR, 2D NMR and HR-ESI-MS spectroscopic analyses. The absolute configurations of 1 and 2 were determined by comparison of their circular dichroism (CD) spectra with the literature. Compounds 1 and 2 showed inhibitory activities against α-glucosidase with the IC₅₀ values of 18.37 and 25.86 μg/mL, respectively.
- Penicillium citrinum,
- isocoumarin,
- antibacterial activity,
- α-glucosidase inhibitory activity
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