Citation: Xia Liwen, Zhao Qing, Ba Mengyu, Hu chaoping, Sun Moran, Yang Hua. A Synthetic Route to Access Allyl-methyl-N-pantothenamide via [2,3]-Wittig Rearrangement[J]. Chinese Journal of Organic Chemistry, ;2019, 39(7): 2035-2041. doi: 10.6023/cjoc201811009 shu

A Synthetic Route to Access Allyl-methyl-N-pantothenamide via [2,3]-Wittig Rearrangement

Xia Liwen ^a,b ,
Zhao Qing ^a,b ,
Ba Mengyu ^a,b ,
Hu chaoping ^a,b ,
Sun Moran ^a,b,, ,
Yang Hua ^a,b

a.
School of Pharmaceutical Science, Zhengzhou University, Zhengzhou 450001
b.
Collaborative Innovation Center of New Drug Research and Safety Evaluation, Zhengzhou 450001

Corresponding author: Sun Moran, sunmr@zzu.edu.cn
Received Date: 5 November 2018
Revised Date: 17 January 2019
Available Online: 8 July 2019
Fund Project: the National Natural Science Foundation of China 21372205the Basic Research Project of Science and Technology Department of Henan Province 132300410028Project supported by the National Natural Science Foundation of China (Nos. 21372205, 21302175) and the Basic Research Project of Science and Technology Department of Henan Province (No. 132300410028)the National Natural Science Foundation of China 21302175

Figures(7)

The synthetic route of allyl-methyl-N-pantothenamide (1) featuring[2,3]-Wittig rearrangement and palladium catalyzed formate reduction to assemble the requisite quaternary carbon with adjacent secondary alcohol has been reported. Our strategy presents a facile synthetic route to access 1 in 10 steps, which also provide a novel inspiration to construct chiral quaternary carbon via asymmetrical[2,3]-Wittig rearrangement.
- [2,3]-Wittig rearrangement,
- N-pantothenamide,
- chiral tertiary carbon,
- antimicrobial
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