Citation: Ji Xiaoming, Shi Guangfa, Zhang Yanghui. Progress of Trifluoromethylation Using Trifluoroacetic Acid and Its Derivatives as CF₃-Sources[J]. Chinese Journal of Organic Chemistry, ;2019, 39(4): 929-939. doi: 10.6023/cjoc201810033 shu

Progress of Trifluoromethylation Using Trifluoroacetic Acid and Its Derivatives as CF₃-Sources

a.
School of Chemical Science and Engineering, Tongji University, Shanghai 200092
b.
Shanghai Key Laboratory of Chemical Assessment and Sustainability, Tongji University, Shanghai 200092

Corresponding author: Zhang Yanghui, zhangyanghui@tongji.edu.cn
Received Date: 25 October 2018
Revised Date: 6 December 2018
Available Online: 21 April 2018
Fund Project: the National Natural Science Foundation of China 21672162Project supported by the National Natural Science Foundation of China (Nos.21372176, 21672162)the National Natural Science Foundation of China 21372176

Figures(30)

Organic molecules containing trifluoromethyl groups often exhibit unique physical and chemical properties, and have found extensive applications. Trifluoroacetic acid and its derivatives have advantages including low cost, ready availability and high stability. Furthermore, CO₂ is the byproduct. Therefore, trifluoroacetic acid and its derivatives are ideal trifluoromethylating reagents, and have great application potentials. The progress of trifluoromethylation reactions using trifluoroacetic acid and its derivatives as CF₃-sources is reviewed, including the reactions of C-X (X=Br and I), C-H, and C=X (X=C, O). The mechanisms are also introduced.
- trifluoroacetic acid,
- CF₃-sources,
- trifluoromethylation reaction,
- C-H activation,
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Progress of Trifluoromethylation Using Trifluoroacetic Acid and Its Derivatives as CF3-Sources

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Progress of Trifluoromethylation Using Trifluoroacetic Acid and Its Derivatives as CF₃-Sources