Citation: Zheng He, Zhou Yuke, Lin Xianfu, Wu Qi. Recent Developments in Protein Engineering and Catalytic Oxidations of Baeyer-Villiger Monooxygenase[J]. Chinese Journal of Organic Chemistry, ;2019, 39(4): 903-915. doi: 10.6023/cjoc201810023 shu

Recent Developments in Protein Engineering and Catalytic Oxidations of Baeyer-Villiger Monooxygenase

Zheng He ^a,b ,
Zhou Yuke ^a ,
Lin Xianfu ^a ,
Wu Qi ^a,,

a.
Department of Chemistry, Zhejiang University, Hangzhou 310027
b.
Shanghai Institute for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031

Corresponding author: Wu Qi, llc123@zju.edu.cn
Received Date: 19 October 2018
Revised Date: 13 December 2018
Available Online: 28 April 2018
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21472169, 21574113)the National Natural Science Foundation of China 21472169the National Natural Science Foundation of China 21574113

Figures(22)

Baeyer-Villiger monooxygenase (BVMO) is an important biocatalyst for Baeyer-Villiger oxidation of various organic ketone/aldehyde compounds, and sulfur, selenium, or boron-containing heteroatoms compounds. As an indispensable tool, BVMO-catalyzed oxidation displays some advantages, such as high selectivity, mild reaction conditions and high efficiency, leading to wide applications into the synthesis of chiral compounds. In recent years, bioinformatics analysis and genome mining have been used to find more novel BVMOs from microorganisms. Besides natural substrates, these BVMOs can accept various organic compounds showing wide substrate scope. Meanwhile, protein engineering has been widely used to improve the catalytic performance of BVMOs, such as the expanded substrate scope, high thermostability and activity, high stereo-, regio-and chemo-selectivities. Based on the Baeyer-Villiger oxidation reaction with different substrate structures, the recent advancements in the research on the catalytic oxidation of wild type and protein-engineered BVMOs in the past five years are summarized.
- Baeyer-Villiger monooxygenase,
- Baeyer-Villiger oxidation,
- biocatalysis,
- asymmetric synthesis,
- protein engineering
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