Citation: Zhou Xiang, Zhou Fei, Jia Xiaoliang, Yu Jiawei, Shen Qi, Zhang Yunxiao, Shi Weimin. Solvent-Free Aldol Reaction of β-Porphyrin Formaldehyde with Ketone[J]. Chinese Journal of Organic Chemistry, ;2019, 39(7): 2084-2088. doi: 10.6023/cjoc201810004 shu

Solvent-Free Aldol Reaction of β-Porphyrin Formaldehyde with Ketone

College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052

Corresponding author: Zhang Yunxiao, zhangyx@zzu.edu.cn Shi Weimin, shiweimin@zzu.edu.cn
Received Date: 5 October 2018
Revised Date: 18 January 2019
Available Online: 8 July 2019
Fund Project: the Science and Technology Planning Project of Henan Province of China 192102310141Project supported by the Science and Technology Planning Project of Henan Province of China (No. 192102310141)

Figures(2)

A convenient approach for the synthesis of β-substituted α, β-unsaturated carbonyl porphyrin compounds via base-catalyzed aldol reaction was developed. By this method, a series of β-substituted α, β-unsaturated carbonyl porphyrin compounds were constructed using β-porphyrin formaldehyde and ketones with moderate to excellent yields under mild reaction conditions, especially solvent-free, and good functional group tolerance. Furthermore, this process was successfully applied to the reactions of different metal porphyrin which have been reported to have poor reaction effects with good yields.
- metal porphyrin,
- α, β-unsaturated carbonyl,
- aldol reaction,
- solvent-free
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