Citation: Li Chun, Wang Mengna, Lu Xunhua, Yang Yuanyong, Zhang Lin. Pd-Catalyzed N-Formylation of Amines with N, N-Dimethylformamide[J]. Chinese Journal of Organic Chemistry, ;2019, 39(4): 1109-1115. doi: 10.6023/cjoc201809020 shu

Pd-Catalyzed N-Formylation of Amines with N, N-Dimethylformamide

Li Chun ^a,b ,
Wang Mengna ^a ,
Lu Xunhua ^a ,
Yang Yuanyong ^a ,
Zhang Lin ^a,b,,

a.
School of Pharmacy, Guizhou Medical University, Guiyang 550004
b.
State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang 550014

Corresponding author: Zhang Lin, gmulinzhang@163.com
Received Date: 15 September 2018
Revised Date: 30 November 2018
Available Online: 7 April 2018
Fund Project: the National Natural Science Foundation of China 21601039Project supported by the National Natural Science Foundation of China (Nos. 21562010, 21601039)the National Natural Science Foundation of China 21562010

Figures(1)

A highly efficient protocol for the transamidation of N, N-dimethylformamide (DMF) and amines has been developed, utilizing a catalytic amount Pd(OAc)₂. This methodology has a broad substrate scope for aliphatic, aromatic, and heterocyclic amines. And this process is simple and easily performed without solvent and co-catalyst.
- Pd(OAc)₂,
- N, N-dimethylformamide (DMF),
- amines,
- N-formylation
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