Citation: Gao Yangguang, Cao Zhou, Han Zhongxiang, Zhang Qiang, Hu Jie, Guo Rui, He Xianran, Ding Fei, You Qingliang, Zhang Yongmin. Synthesis of Azidosphingosine from D-Galactose or L-Arabinose[J]. Chinese Journal of Organic Chemistry, ;2019, 39(2): 390-396. doi: 10.6023/cjoc201808044 shu

Synthesis of Azidosphingosine from D-Galactose or L-Arabinose

Gao Yangguang ^a,, ,
Cao Zhou ^a ,
Han Zhongxiang ^a ,
Zhang Qiang ^a ,
Hu Jie ^a ,
Guo Rui ^b ,
He Xianran ^a ,
Ding Fei ^a ,
You Qingliang ^c ,
Zhang Yongmin ^a,d,

a.
Institute for Interdisciplinary Research, Jianghan University, Wuhan 430056
b.
Institute of Environment and Health, Jianghan University, Wuhan 430056
c.
Key Laboratory of Optoelectronic Chemical Materials and Devices of Ministry of Education, Jianghan University, Wuhan 430056
d.
Institut Parisien de Chimie Moléculaire, Sorbonne Université, Paris 75005

Corresponding author: Gao Yangguang, sunlt413@jhun.edu.cn
Received Date: 31 August 2018
Revised Date: 20 September 2018
Available Online: 19 February 2018
Fund Project: Project supported by the National Natural Science Foundation of China No.21602082Project supported by the National Natural Science Foundation of China (No. 21602082)

Figures(3)

Synthesis of azidosphingosine has been described from D-galactose and L-arabinose with an overall yields of 27% an 20%, respectively. Our strategy features olefin cross-metathesis reaction, radical-induced isomerization, appel reaction, and azido replacement.
- sphingosine,
- synthesis,
- carbohydrate,
- olefin cross-metathesis,
- replacement
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沈阳化工大学材料科学与工程学院沈阳 110142