Citation: Ju Zhiyu, Shu Penghua, Xie Zhiyu, Jiang Yuqing, Tao Weijie, Xu Zhihong. A Flavone-Based Fluorescent Probe for Hydrazine and Its Bioimaging in Live Cells[J]. Chinese Journal of Organic Chemistry, ;2019, 39(3): 697-702. doi: 10.6023/cjoc201808035 shu

A Flavone-Based Fluorescent Probe for Hydrazine and Its Bioimaging in Live Cells

Ju Zhiyu ^a,, ,
Shu Penghua ^a ,
Xie Zhiyu ^a ,
Jiang Yuqing ^a ,
Tao Weijie ^a ,
Xu Zhihong ^a,b,,

a.
Xuchang Municipality Key Laboratory of Chemo/Biosensing and Detection, School of Chemistry and Chemical Engineering, Xuchang University, Xuchang 461000
b.
College of Chemistry and Molecular Engineering, Zhengzhou University, Zhengzhou 450052

Corresponding author: Ju Zhiyu, juz1696@163.com Xu Zhihong, xuzhihong1980@yahoo.com
Received Date: 28 August 2018
Revised Date: 3 November 2018
Available Online: 25 March 2018
Fund Project: the National Natural Science Foundation of China U1304202the National Natural Science Foundation of China 21702178the Program for Science and Technology Innovation Talents in Universities of Henan Province 15HASTIT002the Science and Technology Project of Henan Province 182102310066Project supported by the Science and Technology Project of Henan Province (Nos. 182102311108, 182102310066), the Program for Science and Technology Innovation Talents in Universities of Henan Province (No. 15HASTIT002), and the National Natural Science Foundation of China (Nos. 21702178, U1304202)the Science and Technology Project of Henan Province 182102311108

Figures(8)

A 3-hydroxyflavonoid esters HFBA was synthesized by the reaction of 2-hydroxyacetophenone with p-methyl benzaldehyde, and its structure was characterized by NMR and high resolution mass spectrometer. The recognition behaviors of HFBA to hydrazine were investigated and the results show that HFBA exhibits good selectivity and sensitivity to N₂H₄ with fast response and good anti-interference ability in DMSO/PBS buffer (pH=7.4). Furthermore, the detection limit of HFBA for hydrazine was estimated to be 0.11 μmol/L, and the probe HFBA was successfully applied for the imaging of hydrazine in living cells.
- flavone,
- fluorescence,
- hydrazine,
- biological imaging
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