Citation: Sun Xiaoli, Sun Zhenhua, Han Minmin, Han Jing, He Weimin, Chen Jie, Deng Hongmei, Shao Min, Zhang Hui, Cao Weiguo. Synthesis of Perfluoroalkylated Fluorenes with Phosphonate Group via One-Pot Synthesis Process[J]. Chinese Journal of Organic Chemistry, ;2019, 39(1): 192-199. doi: 10.6023/cjoc201808028 shu

Synthesis of Perfluoroalkylated Fluorenes with Phosphonate Group via One-Pot Synthesis Process

Sun Xiaoli ^a ,
Sun Zhenhua ^a ,
Han Minmin ^b ,
Han Jing ^a ,
He Weimin ^a ,
Chen Jie ^a ,
Deng Hongmei ^c ,
Shao Min ^c ,
Zhang Hui ^a,c,, ,
Cao Weiguo ^a,d,e,,

a.
Department of Chemistry, Shanghai University, Shanghai 200444
b.
Qianweichang College, Shanghai University, Shanghai 200444
c.
Laboratory for Microstructures, Instrumental Analysis and Research Center of Shanghai University, Shanghai 200444
d.
State Key Laboratory of Organometallic Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032
e.
Key Laboratory of Organofluorine Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032

Corresponding author: Zhang Hui, wgcao@staff.shu.edu.cn Cao Weiguo, wgcao@staff.shu.edu.cn
Received Date: 24 August 2018
Revised Date: 13 September 2018
Available Online: 19 January 2018
Fund Project: the National Natural Science Foundation of China 21672138Project supported by the National Natural Science Foundation of China (No. 21672138)

Figures(3)

A simple and versatile metal-free protocol for the synthesis of perfluoroalkyated fluorene derivatives bearing phosphonate group is achieved. The reactions proceeded via one-pot three-component condensation of indenones, fluorinated alkynylphosphonates and malononitrile under mild conditions. This protocol is highly regioselective, operationally facile and applicable to a variety of indenones in good to excellent yields.
- multicomponent reactions (MCRs),
- one-pot synthesis,
- perfluoroalkynyl phosphonate,
- fluorene
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