Citation: Xu Yiwen, Zhang Peng, Liu Caiqin, Lin Chen, Lin Xiaoyan, Ke Fang. Nickel-Catalyzed Synthesis of Quinazolinone Derivatives in Polyethylene Glycol 200[J]. Chinese Journal of Organic Chemistry, ;2019, 39(2): 538-543. doi: 10.6023/cjoc201808023 shu

Nickel-Catalyzed Synthesis of Quinazolinone Derivatives in Polyethylene Glycol 200

Department of Pharmacy, Fujian Medical University, Fuzhou 350004

Corresponding author: Ke Fang, kefang@163.com
Received Date: 20 August 2018
Revised Date: 10 September 2018
Available Online: 10 February 2018
Fund Project: the Natural Science Foundation of Fujian Province 2016Y9051the Research Fund of Fujian Medical University 2015MP008the Natural Science Foundation of Fujian Province 2017J01820Project supported by the Natural Science Foundation of Fujian Province (Nos. 2016J01686, 2016J01372, 2016Y9051, 2017J01820) and the Research Fund of Fujian Medical University (No. 2015MP008)the Natural Science Foundation of Fujian Province 2016J01686the Natural Science Foundation of Fujian Province 2016J01372

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A simple and economic method for synthesizing quinazolinones from substituted 2-halobenzoic acids and amidines was developed by nickel-catalysis in wet polyethylene glycol 200 (PEG 200) as an eco-friendly medium. The present methodology is operationally simple, non-toxic and non-irritative, and varieties of quinazolinone derivatives were obtained in high yields of up to 94%.
- polyethylene glycol 200 (PEG 200),
- quinazolinone,
- nickel chloride,
- 2-halobenzoic acid,
- amidine
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