Citation: Zhang Faguang, Peng Xing, Ma Jun'an. Recent Advances in the Synthesis of CF₃-Substituted Triazoles and Tetrazoles[J]. Chinese Journal of Organic Chemistry, ;2019, 39(1): 109-116. doi: 10.6023/cjoc201808007 shu

Recent Advances in the Synthesis of CF₃-Substituted Triazoles and Tetrazoles

Tianjin Key Laboratory of Molecular Optoelectronic Sciences, and Tianjin Collaborative Innovation Center of Chemical Science & Engineering, Department of Chemistry, Tianjin University, Tianjin 300072

Corresponding author: Zhang Faguang, zhangfg1987@tju.edu.cn Ma Jun'an, majun_an68@tju.edu.cn
Received Date: 7 August 2018
Revised Date: 14 September 2018
Available Online: 12 January 2018
Fund Project: the National Natural Science Foundation of China 21772142the National Natural Science Foundation of China 21532008the National Basic Research Program of China 973 Program, No. 2014CB745100Project supported by the National Natural Science Foundation of China (Nos. 21472137, 21532008, 21772142) and the National Basic Research Program of China (973 Program, No. 2014CB745100)the National Natural Science Foundation of China 21472137

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Trifluoromethylated triazoles and tetrazoles have emerged as increasingly important heterocycles in pharmaceuticals, agrochemicals, catalysis, and materials. As a consequence, great attention has been paid to the efficient synthesis of these valuable CF₃-containing molecules. Herein, the advances in the past decade towards the synthesis of CF₃-substituted triazoles and tetrazoles are summarized. The remarkable progress in the utilization of versatile CF₃-functionalized building blocks including CF₃-containing alkynes, CF₃-containing carbonyl compounds, CF₃-containing pyrones and trifluorodiazoethane (CF₃CHN₂) is demonstrated accordingly.
- trifluoromethyl group,
- triazole,
- tetrazole,
- fluorine-containing heterocycle,
- cycloaddition
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Recent Advances in the Synthesis of CF₃-Substituted Triazoles and Tetrazoles