Citation: Yan Shiqiang, Xie Mingxian, Wang Yujie, Li Yingxia. Research on the Semi-synthesis of Pectolinarin from Scutellarin[J]. Chinese Journal of Organic Chemistry, ;2019, 39(2): 412-418. doi: 10.6023/cjoc201807051 shu

Research on the Semi-synthesis of Pectolinarin from Scutellarin

School of Pharmacy, Fudan University, Shanghai 201203

Corresponding author: Li Yingxia, liyx417@fudan.edu.cn
Received Date: 27 July 2018
Revised Date: 14 September 2018
Available Online: 14 February 2018
Fund Project: Project supported by the National Natural Science Foundation of China (No. 81773576)Project supported by the National Natural Science Foundation of China No. 81773576

Figures(5)

As the representative flavonoid and flavonoid glycoside of Chinese medicine Cirsium japonicum, pectolinarigenin and pectolinarin have important bioactivities. In this paper, the efficient semi-synthesis of pectolinarigenin had been achieved starting from commercially available scutellarin via a linear reaction sequence of 3 steps with the overall yield of 69.5%, wherein carboxyl esterification, selective hydroxy protecting, and glycosidic bond hydrolyzation were used. Afterwards, the chemical synthesis of pectolinarin had been accomplished by the glycosylation of pectolinarigenin and benzobromorutinose.
- scutellarin,
- pectolinarigenin,
- pectolinarin,
- flavonoids,
- semi-synthesis
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