Citation: Wu Ningjie, Cheng Long, Wang Jian, Yu Jiping, Xing Jiahua, Xu Tianming, Wei Youchang. Synthesis and Insecticidal Activity of Novel 4-Arylamino Pyrimidine Derivatives[J]. Chinese Journal of Organic Chemistry, ;2019, 39(3): 852-860. doi: 10.6023/cjoc201807044 shu

Synthesis and Insecticidal Activity of Novel 4-Arylamino Pyrimidine Derivatives

Wu Ningjie ^a ,
Cheng Long ^b ,
Wang Jian ^b ,
Yu Jiping ^a ,
Xing Jiahua ^a ,
Xu Tianming ^a ,
Wei Youchang ^a,b,,

a.
Sinochem Lantian Zhejiang Research Institute of Chemical Industry Co. Ltd., Hangzhou 310023
b.
College of Chemical Engineering, Zhejiang University of Technology, Hangzhou 310014

Corresponding author: Wei Youchang, weiyouchang@sinochem.com
Received Date: 24 July 2018
Revised Date: 22 October 2018
Available Online: 25 March 2018
Fund Project: the China Postdoctoral Science Foundation 2016M601971Project supported by the China Postdoctoral Science Foundation (No. 2016M601971)

Figures(3)

A series of novel 4-arylamino pyrimidine derivatives were synthesized using substituted aniline as starting material via diazotization, Meerwein arylation, isothiocyanation, addition, methylation and cyclization. The preliminary results of insecticidal activities indicated that most of the compounds exhibited 100% insecticidal activitiy against Mythimna separata Walker at 500 mg/L. At 20 mg/L, N-(2-chloro-4-fluorophenyl) -2, 6-dimethyl-5-(4-phenoxy-2-(trifluoromethyl) phenyl) -pyrimidin-4-amine (6h) exhibited 80% and 60% mortality against Mythimna separata Walker and Plutella xylostella Linnaeus, respectively.
- 4-arylamino pyrimidine,
- pyrimidinamine,
- synthesis,
- insecticidal
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