Citation: Zhang Juan, Wang Biyun, Liu Yisen, Cao Song. Stereoselective Synthesis of Z-Fluorostyrene Derivatives via Nickel-Catalyzed Cross-Coupling of gem-Difluorostyrenes with Organozinc Reagents[J]. Chinese Journal of Organic Chemistry, ;2019, 39(1): 249-256. doi: 10.6023/cjoc201807013 shu

Stereoselective Synthesis of Z-Fluorostyrene Derivatives via Nickel-Catalyzed Cross-Coupling of gem-Difluorostyrenes with Organozinc Reagents

Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology(ECUST), Shanghai 200237

Corresponding author: Cao Song, scao@ecust.edu.cn
Received Date: 6 July 2018
Revised Date: 5 September 2018
Available Online: 17 January 2018
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21472043, 21272070)the National Natural Science Foundation of China 21472043the National Natural Science Foundation of China 21272070

Figures(3)

An efficient method for the synthesis of various Z-fluorostyrene derivatives via nickel-catalyzed cross-coupling of gem-difluorostyrenes with organozinc reagents with the assistance of LiCl was developed. The reaction proceeds efficiently under mild condition, affording monofluoroalkenes in moderate to good yields. This novel method exhibits good functional group compatibility and excellent stereoselectivity.
- gem-difluorostyrenes,
- nickel-catalyzed,
- organozinc reagents,
- monofluoroalkenes
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