Citation: Huang Pengmian, Zhou Zhihui, Du Yonglei, Pang Huailin, Lü Liang. Synthesis and Fungicidal Activity of N-Alkoxyl Amide Derivatives[J]. Chinese Journal of Organic Chemistry, ;2019, 39(3): 867-872. doi: 10.6023/cjoc201806029 shu

Synthesis and Fungicidal Activity of N-Alkoxyl Amide Derivatives

a.
School of Chemistry and Food Engineering, Changsha University of Science and Technology, Changsha 410114
b.
CAC Shanghai International Trading Co., Ltd., Shanghai 200335

Corresponding author: Huang Pengmian, huangpengmian@126.com Lü Liang, liang_lv@cacch.com
Received Date: 19 June 2018
Revised Date: 5 September 2018
Available Online: 26 March 2018
Fund Project: the Changsha Science and Technology Project kq1801052the Changsha Science and Technology Project kq1801163Project supported by the Changsha Science and Technology Project (Nos. kq1801163, kq1801052) and the Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources (No. 2018KJY08)the Hunan Provincial Engineering Research Center for Food Processing of Aquatic Biotic Resources 2018KJY08

Figures(2)

In order to find lead compounds with high fungicidal activity, the phenyl moiety of pydiflumetofen was replaced by substituted 1-phenyl-3-hydroxylpyrazole moiety of pyraclostrobin according to the method of active substructure combination. 12 novel N-alkoxyl amides were synthesized and their structures were confirmed by ¹H NMR, ¹³C NMR and HRMS. Preliminary fungicidal activity screening results showed that some analogues exhibited certain fungicidal activity against Phakopsora pachyrhizi, Pseudoperonospora cubensis or Erysiphe cichoracearum, compound 3a displayed 95% protective effect against Erysiphe cichoracearum at 100 mg/L.
- pydiflumetofen,
- amide,
- pesticide,
- fungicidal activity
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沈阳化工大学材料科学与工程学院沈阳 110142