Citation: Su Lin, Hou Wei. Progress in the Synthesis of Cinnoline Derivatives[J]. Chinese Journal of Organic Chemistry, ;2019, 39(2): 363-376. doi: 10.6023/cjoc201806021 shu

Progress in the Synthesis of Cinnoline Derivatives

Su Lin ,
Hou Wei ^,

College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou 310014

Corresponding author: Hou Wei, houwei@zjut.edu.cn
Received Date: 15 June 2018
Revised Date: 2 August 2018
Available Online: 10 February 2018
Fund Project: the China Postdoctoral Science Foundation 2017M612024Project supported by the Scientific Start-Up Funding from Zhejiang University of Technology (No. 2017116002229) and the China Postdoctoral Science Foundation (No. 2017M612024)the Scientific Start-Up Funding from Zhejiang University of Technology 2017116002229

Figures(15)

Cinnolines are "privileged scaffold" in new material and drug research, and development for their extensive biological activities such as anticancer, antibacterial, antiviral, anti-inflammatory, and sedative activities and good electron-accepting ability. As a result, the development of new synthetic routes to this important structure has been actively investigated in recent years. Especially, the C-H functionalization strategy has promoted the development of new methods greatly. The recent advances of the synthetic methods to cinnolines based on different synthetic strategies and raw materials are reviewed.
- cinnolines,
- C-H functionalization,
- coupling,
- tandem reaction
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沈阳化工大学材料科学与工程学院沈阳 110142