Citation: Kong Lichun, Zhou Yulu, Luo Fang, Zhu Gangguo. Recent Advances on Oxidative Radical Addition to Aldehydes[J]. Chinese Journal of Organic Chemistry, ;2018, 38(11): 2858-2865. doi: 10.6023/cjoc201805061 shu

Recent Advances on Oxidative Radical Addition to Aldehydes

Key Laboratory of the Ministry of Education for Advanced Catalysis Materials, Department of Chemistry, Zhejiang Normal University, Jinhua 321004

Corresponding author: Zhu Gangguo, gangguo@zjnu.cn
Received Date: 31 May 2018
Revised Date: 27 June 2018
Available Online: 24 November 2018
Fund Project: the National Natural Science Foundation of China 21672191Project supported by the National Natural Science Foundation of China (No. 21672191)

Figures(8)

Ketones are ubiquitous chemical entries in natural products, biologically active molecules, and functional materials. As such, developing operationally simple and general methods for the synthesis of these scaffolds is highly desiable. Recently, oxidative radical addition to aldehydes has emerged as a highly efficient strategy for the direct access of ketones. The strategy features a formal 1, 2-hydrogen atom transfer of resulting alkoxy radicals, followed by single electron transfer oxidation and deprotonation to give various cyclic or acyclic ketones in promising yields with a broad substrate scope. Recent advances in this area, including both intramolecular and intermolecular versions, are discussed herein.
- aldehyde,
- radical addition,
- ketone,
- 1, 2-hydrogen atom transfer,
- single electron transfer
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