Citation: Wang Yinglei, Wan Zijuan, Luo Jun. Synthesis of Pyrazolo[1, 2-b]phthalazine-5, 10-diones Catalyzed by Poly(ethylene glycol) Grafted 4-Dimethylaminopyridine Functionalized Ionic Liquid[J]. Chinese Journal of Organic Chemistry, ;2019, 39(2): 521-526. doi: 10.6023/cjoc201805052 shu

Synthesis of Pyrazolo[1, 2-b]phthalazine-5, 10-diones Catalyzed by Poly(ethylene glycol) Grafted 4-Dimethylaminopyridine Functionalized Ionic Liquid

a.
School of Biological and Chemical Engineering, Nanyang Institute of Technology, Nanyang 473004
b.
School of Chemical Engineering, Nanjing University of Science and Technology, Nanjing 210094

Corresponding author: Wang Yinglei, wangyinglei2014@163.com
Received Date: 29 May 2018
Revised Date: 9 July 2018
Available Online: 19 February 2018
Fund Project: the National Natural Science Foundation of China 21002050the Key Scientific Research Projects of Henan Province 17B150007the Key Project of Science and Technology of Henan Province 182102310601Project supported by the National Natural Science Foundation of China (No.21002050) the Key Project of Science and Technology of Henan Province (No. 182102310601) and the Key Scientific Research Projects of Henan Province (No. 17B150007)

Figures(4)

A novel poly(ethylene glycol) grafted 4-dimethylaminopyridine functionalized ionic liquid ([DMAP-PEG₁₀₀₀-DIL] [BF₄]) was prepared and characterized by ¹H NMR, ¹³C NMR, FT-IR and ESI-MS. In the presence of[DMAP-PEG₁₀₀₀-DIL] [BF₄], various substituted aromatic aldehyde could react with malononitrile (or ethyl cyanoacetate) and phthalhydrazide in water to obtain a series of pyrazolo[1, 2-b]phthalazine-5, 10-dione derivatives with 85%~96% yields. The mild reaction conditions, high stable and recyclable ionic liquids, environmental friendliness are advantages of this methodology.
- poly(ethylene glycol),
- ionic liquid,
- 4-dimethylaminopyridine,
- pyrazolo[1, 2-b]phthalazine-5, 10-dione,
- aqueous media
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