Citation: Xiong Fei, Li Li. Advances in Development of Chiral Sensors[J]. Chinese Journal of Organic Chemistry, ;2018, 38(11): 2927-2936. doi: 10.6023/cjoc201805042 shu

Advances in Development of Chiral Sensors

Xiong Fei ,
Li Li ^,

Beijing Key Laboratory of Active Substances Discovery and Druggability Evaluation, Institute of Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050

Corresponding author: Li Li, annaleelin@imm.ac.cn
Received Date: 20 May 2018
Revised Date: 5 June 2018
Available Online: 22 November 2018
Fund Project: the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences 2016-I2M-3-009Project supported by the Chinese Academy of Medical Sciences (CAMS) Innovation Fund for Medical Sciences (No. 2016-I2M-3-009)

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Chiral compounds play an essential role in asymmetric synthesis, biology, medical field and pharmacology. It is necessary to establish fast, sensitive and high enantioselective chiral analysis methods. Chiral sensors, which could determine the absolute configuration and the value of enantiomeric excess of enantiomers, have the advantages of simple, rapid, sensitive and real-time. Herein, the review is focused on the recent progress of chiral fluorescent sensors, circular dichroism sensors, UV-Vis sensors, NMR sensors and MS sensors. Their characteristics, sensing mechanism and applications in chiral recognition are reviewed, and the prospects of chiral sensors are also discussed.
- chiral sensor,
- chiral compound,
- chiral recognition,
- enantiomeric excess,
- absolute configuration
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