Citation: Hu Xinyu, Yang Bobin, Yao Wei, Wang Dawei. Alanine Triazole Mn-Catalyzed Coupling/Aromatization of Quinone Methides[J]. Chinese Journal of Organic Chemistry, ;2018, 38(12): 3296-3301. doi: 10.6023/cjoc201805019 shu

Alanine Triazole Mn-Catalyzed Coupling/Aromatization of Quinone Methides

Hu Xinyu ^† ,
Yang Bobin ^† ,
Yao Wei ,
Wang Dawei ^,

Key Laboratory of Synthetic and Biological Colloid, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122

Corresponding author: Wang Dawei, wangdw@jiangnan.edu.cn
Received Date: 8 May 2018
Revised Date: 18 July 2018
Available Online: 14 December 2018
Fund Project: Project supported by the National Natural Science Foundation of China (No. 2176111), the Fundamental Research Funds for the Central Universities (No. JUSRP 51627B)Fundamental Research Funds for the Central Universities JUSRP51627Bthe National Natural Science Foundation of China 2176111

Figures(2)

Alanine triazole Mn-catalyzed 1, 6-conjugate coupling/aromatization of para-quinone methides was developed with good to high yields under mild conditions. This protocol provided an efficient and practical route to the synthetically interesting functionalized methines and their analogues. Preliminary mechanistic experiments revealed 1, 6-conjugate addition of nucleophiles to para-quinone methides (p-QMs). The manganese was acted as the Lewis acid.
- quinone methide,
- manganese,
- ligand,
- triazole
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