Citation: Xu Zhaohui, Chen Feibiao, Li Yuyu, Huang Qingshui, Liao Chuanwen. "One-Pot" Synthesis of 5-(1-Phenyl-3-phenylprop-2-ynyl)-2, 2-dimethyl-1, 3-dioxane-4, 6-dione Catalyzed by Copper Acetate[J]. Chinese Journal of Organic Chemistry, ;2018, 38(11): 3101-3105. doi: 10.6023/cjoc201804049 shu

"One-Pot" Synthesis of 5-(1-Phenyl-3-phenylprop-2-ynyl)-2, 2-dimethyl-1, 3-dioxane-4, 6-dione Catalyzed by Copper Acetate

a.
Chemistry and Chemical Engineering Department, Jiangxi Normal University, Nanchang 330022
b.
Clinical Laboratory, First Affiliated Hospital of Nanchang University, Nanchang 330026
c.
Department of General Surgery, Jiangxi Province People's Hospital, Nanchang 330006

Corresponding author: Liao Chuanwen, gotoxzh@163.com
Received Date: 30 April 2018
Revised Date: 4 June 2018
Available Online: 24 November 2018
Fund Project: the National Natural Science Foundation of China 81760297the Graduate Innovation Fundation of Jiangxi Province YC2015-B023Project supported by the National Natural Science Foundation of China (No. 81760297), the Graduate Innovation Fundation of Jiangxi Province (No. YC2015-B023) and the Science and Technology Research Project of Jiangxi Provincial Education Department (No. GJJ170170)the Science and Technology Research Project of Jiangxi Provincial Education Department GJJ170170

Figures(1)

In the presence of copper acetate, ten 5-(1-phenyl-3-phenylprop-2-ynyl)-2, 2-dimethyl-1, 3-dioxane-4, 6-dione derivatives were synthesized via the three component one-pot reaction of aldehydes with 2, 2-dimethyl-1, 3-dioxane-4, 6-dione and phenylacetylene by using Na-ascorbate as a reductant. The reaction has the advantages of high yields (65%~86%), mild conditions, simple operation and environmental friendliness. It provides an effective method for the synthesis of 5-(1-phenyl-3-phenylprop-2-ynyl)-2, 2-dimethyl-1, 3-dioxane-4, 6-dione derivatives.
- one-pot,
- copper acetate,
- 2, 2-dimethyl-1, 3-dioxane-4, 6-dione,
- 5-(1-phenyl-3-phenylprop-2-ynyl)-2, 2-dimethyl-1, 3-dioxane-4, 6-dione
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