Citation: Zhou Jianping, Wu Baogeng, Zhou Zhikuan, Tian Jiangwei, Yuan Aihua. A Novel Naphthalene-Fused Boron Dipyrromethene (BODIPY)-Based Near Infrared Fluorescent Probe for Detecting Fluoride in Living Cells[J]. Chinese Journal of Organic Chemistry, ;2019, 39(2): 406-411. doi: 10.6023/cjoc201804043 shu

A Novel Naphthalene-Fused Boron Dipyrromethene (BODIPY)-Based Near Infrared Fluorescent Probe for Detecting Fluoride in Living Cells

a.
School of Environmental and Chemical Engineering, Jiangsu University of Science and Technology, Zhenjiang 212003
b.
Department of Traditional Chinese Medicine, China Pharmaceutical University, Nanjing 211198

Corresponding author: Zhou Jianping, zkzhou@just.edu.cn Tian Jiangwei, jwtian@cpu.edu.cn Yuan Aihua, aihua.yuan@just.edu.cn
Received Date: 25 April 2018
Revised Date: 17 July 2018
Available Online: 11 February 2018
Fund Project: China Postdoctoral Science Foundation No. 2017M621662Project supported by the National Natural Science Foundation of China (Nos. 21501073, 21775166, 51672114) and the China Postdoctoral Science Foundation (No. 2017M621662)Project supported by the National Natural Science Foundation of China Nos. 21501073Project supported by the National Natural Science Foundation of China 21775166Project supported by the National Natural Science Foundation of China 51672114

Figures(5)

A colorimetric and fluorescent turn-off chemosensor for fluoride based on novel naphthalene-fused boron dipyrromethene (BODIPY) 5 was designed and synthesized. In various anions, only upon addition of fluoride, the UV-Vis absorption peak of probe 5 red-shifted 100 nm, reaching the near infrared (NIR) region. Thus, it can be used as naked-eye detector for fluoride ion. In the fluorescence test, upon addition of fluoride, the fluorescence of probe 5 quenched significantly. Confocal fluorescence microscopy experiments demonstrate that 5 can be used for monitoring fluoride in living cells.
- boron dipyrromethene (BODIPY),
- near infrared (NIR),
- fluoride,
- fluorescent sensor
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