Citation: Xu Tongxiu, Wang Yan, Tian Keqing, Wang Ranran, Yan Jingyi, Zhang Ping. Synthesis and Antimicrobial Activity of 2-Substituted-phenyl-3-(N, N-dimethylformamido)-4-methyl-1, 5-benzothiazepine[J]. Chinese Journal of Organic Chemistry, ;2018, 38(10): 2731-2735. doi: 10.6023/cjoc201804029 shu

Synthesis and Antimicrobial Activity of 2-Substituted-phenyl-3-(N, N-dimethylformamido)-4-methyl-1, 5-benzothiazepine

Xu Tongxiu ^a ,
Wang Yan ^a ,
Tian Keqing ^c ,
Wang Ranran ^a ,
Yan Jingyi ^b ,
Zhang Ping ^a,,

a.
College of Chemistry and Materials Science, Hebei Normal University, Shijiazhuang 050024
b.
College of Life Science, Hebei Normal University, Shijiazhuang 050024
c.
Environment and Chemical Engineering, Hebei Chemical and Pharmaceutical College, Shijiazhuang 050026

Corresponding author: Zhang Ping, zhangpingp@sina.com
Received Date: 16 April 2018
Revised Date: 31 May 2018
Available Online: 22 October 2018
Fund Project: the Natural Science Foundation of Hebei Province B2017205100Project supported by the Natural Science Foundation of Hebei Province (No. B2017205100)

Figures(5)

By introducing N, N-dimethylformamido into 1, 5-benzothiazepine, 6 compounds of 2-substituted-phenyl-3-(N, N-dimethylformamido)-4-methyl-1, 5-benzothiazepine 3a~3f were designed and synthesized, Studies on the synthesis conditions of 3a~3f revealed that 3a~3f were dynamic control products. 3a~3f had obvious inhibitory effect on fungi and bacteria especially for Cryptococcus neoformans and Escherichia coli.
- 1, 5-benzothiazepine,
- dynamic control product,
- thermodynamic control product,
- antimicrobical activity
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