Citation: Li Zichen, Zhang Baochang, Zuo Chong, Liu Lei. Studies on Mirror-Image Proteins[J]. Chinese Journal of Organic Chemistry, ;2018, 38(9): 2412-2419. doi: 10.6023/cjoc201804014 shu

Studies on Mirror-Image Proteins

Key Laboratory of Bioorganic Phosphorus Chemistry and Chemical Biology, Ministry of Education, Department of Chemistry, Tsinghua University, Beijing 100084

Corresponding author: Liu Lei, lliu@mail.tsinghua.edu.cn
Received Date: 9 April 2018
Revised Date: 4 May 2018
Available Online: 17 September 2018
Fund Project: the National Key R&D Program of China 2017YFA0505200the National Natural Science Foundation of China 21532004Project supported by the National Key R&D Program of China (No. 2017YFA0505200) and the National Natural Science Foundation of China (Nos. 21750005, 21532004, 91753205)the National Natural Science Foundation of China 21750005the National Natural Science Foundation of China 91753205

Figures(9)

Mirror-image proteins are composed of D-amino acids and glycine. They are the enantiomers of the native L-protein counterparts. Currently mirror-image proteins can not be obtained through recombinant technology and therefore, chemical synthesis is the only way to generate mirror-image proteins. As structurally defined and functionally variable chemical materials, mirror-image proteins have potential applications in racemic crystallography, biomimetic catalysis, soft materials, and diagnostics and therapeutic reagents. The chemical synthesis of mirror-image proteins and the advances in racemic X-ray crystallography, mirror-image drug discovery, as well as mirror-image biological systems are surveyed.
- mirror-image protein,
- protein chemical synthesis,
- racemic crystallography,
- mirror-image phage display,
- mirror-image biosystem
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