Citation: Xu Zhaohui, Li Yuyu, Liu Deyong, Xiao Qiang. Highly Efficent Synthesis of Novel Gastrodine Intermediate Analogues[J]. Chinese Journal of Organic Chemistry, ;2018, 38(11): 3118-3122. doi: 10.6023/cjoc201804005 shu

Highly Efficent Synthesis of Novel Gastrodine Intermediate Analogues

Xu Zhaohui ^a,, ,
Li Yuyu ^a ,
Liu Deyong ^a ,
Xiao Qiang ^b,,

a.
Department of Chemistry and Chemical Engineering, Jiangxi Normal University, Nanchang 330027
b.
Department of Orthpaedics, Jiangxi Province People's Hospital, Nanchang 330006

Corresponding author: Xu Zhaohui, gotoxzh@163.com Xiao Qiang,
Received Date: 2 April 2018
Revised Date: 15 May 2018
Available Online: 5 November 2018
Fund Project: the Science and Technology Research Project of Jiangxi Provincial Education Department GJJ170170the National Natural Science Foundation of China 81760297the Graduate Innovation Fundation of Jiangxi Province YC2015-B023Project supported by the National Natural Science Foundation of China (No. 81760297), the Graduate Innovation Fundation of Jiangxi Province (No. YC2015-B023) and the Science and Technology Research Project of Jiangxi Provincial Education Department (No. GJJ170170)

Figures(2)

Ten gastrodine intermediate analogues were synthesized by the Knoevenagel reaction of 4-formylphenyl(2, 3, 4, 6-tetra-O-acetyl)-β-D-glucoside and 1, 3-dioxane-4, 6-dione with gluconic acid as a catalyst. In this reaction there are many advantages with good to excellent yields (78%~92%), mild conditions, simple operations and environmental friendliness. Additionally, gluconic acid could be recycled and reused many times without lossing its efficiency.
- gluconic acid,
- Knoevenagel reaction,
- 4-formylphenyl (2, 3, 4, 6-tetra-O-acetyl)-β-D-glucoside,
- gastrodine intermediate analogues
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