Citation: Han Yuling, Tong Wenting, Liu Hui, Chen Jianxin. Synthesis of α-(N-Sulfonyl)amino Amides Derivatives Using Carbamoylsilanes as an Amide Source[J]. Chinese Journal of Organic Chemistry, ;2018, 38(8): 1993-2001. doi: 10.6023/cjoc201803054 shu

Synthesis of α-(N-Sulfonyl)amino Amides Derivatives Using Carbamoylsilanes as an Amide Source

College of Chemistry and Material Science, Shanxi Normal University, Linfen 041004

Corresponding author: Chen Jianxin, jjxxcc2002@yahoo.com
Received Date: 30 March 2018
Revised Date: 13 May 2018
Available Online: 3 August 2018
Fund Project: Project supported by the Shanxi Provincal Foundation for Returness Overseas Scientists (No. 0713), the Natural Science Foundation of Shanxi Province (No. 2012011046-9), and the Foundation of the Modern College of Arts and Science, Shanxi Normal University (No. WL2016CXCY-YJ-30)the Natural Science Foundation of Shanxi Province 2012011046-9the Shanxi Provincal Foundation for Returness Overseas Scientists 0713the Foundation of the Modern College of Arts and Science, Shanxi Normal University WL2016CXCY-YJ-30

Figures(1)

α-(N-Sulfonyl)amino amide derivatives are directly synthesized in 71%~89% yields by the reaction of carbamoylsilanes with various N-sulfonylimines in benzene under catalyst-free conditions. The procedure can prepare both tertiary and secondary α-amino amides. A comparison of the results obtained from the N-sulfonylimines containing the variety of alkyl, aryl and heterocyclic ring indicated that the electronic effect was an important factor in the addition reaction, which influenced on the rate and yields of the reaction. The new method is simple and mild procedure, no catalysts conditions, less byproducts and good yields for the preparation of α-aminoamides.
- carbamoylsilane,
- α-amino amide,
- N-sulfonylimine,
- nucleophilic addition,
- synthetic method
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