Citation: Zhang Lüye, Wu Binqiang, Chen Zhangtao, Hu Jinjin, Zeng Xiaofei, Zhong Guofu. Synthesis of 2, 3'-Bisindole Derivatives Catalyzed by TfOH[J]. Chinese Journal of Organic Chemistry, ;2018, 38(8): 2028-2035. doi: 10.6023/cjoc201803036 shu

Synthesis of 2, 3'-Bisindole Derivatives Catalyzed by TfOH

College of Material, Chemistry and Chemical Engineering, Hangzhou Normal University, Hangzhou 310036

Corresponding author: Zeng Xiaofei, chemzxf@hznu.edu.cn Zhong Guofu, zgf@hznu.edu.cn
Received Date: 23 March 2018
Revised Date: 3 May 2018
Available Online: 14 August 2018
Fund Project: the Natural Science Foundation of Zhejiang Province LY18B020015the National Natural Science Foundation of China 21672048Project supported by the National Natural Science Foundation of China (No. 21672048), the Natural Science Foundation of Zhejiang Province (No. LY18B020015)

Figures(4)

A highly efficient TfOH-catalyzed addition of C3-substituted indole derivatives with (1H-indol-2-yl)diphenyl-methanols has been established, leading to the synthesis of a series of potentially bioactive 2, 3'-bisindols in moderate to high yields (48%~89%) and with broad substrate scope under mild conditions. In addition, the furan-2-yldiphenylmethanol could also be applied in the reaction and afforded 2-(5-benzhydrylfuran-2-yl)-1H-indole in good yield.
- addition reaction,
- synthetic method,
- 2, 3'-bisindole derivatives,
- (1H-indol-2-yl)diphenylmethanol,
- TfOH
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