Citation: Dai Yihua, Shen Yanfang, Gao Shuanhu. Cascade Halo-Michael/Aldol Reaction and Its Application in Synthesis[J]. Chinese Journal of Organic Chemistry, ;2018, 38(7): 1608-1625. doi: 10.6023/cjoc201803005 shu

Cascade Halo-Michael/Aldol Reaction and Its Application in Synthesis

a.
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062
b.
Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development, East China Normal University, Shanghai 200062

Corresponding author: Gao Shuanhu, shgao@chem.ecnu.edu.cn
Received Date: 4 March 2018
Revised Date: 2 April 2018
Available Online: 4 July 2018
Fund Project: Project supported by the National Natural Science Foundation of China (No. 21772044), the Program of Shanghai Academic/Technology Research Leader (No. 18XD1401500), the National Young Top-Notch Talent Support Program and the Fundamental Research Funds for the Central Universitiesthe National Natural Science Foundation of China 21772044the Program of Shanghai Academic/Technology Research Leader 18XD1401500

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Michael addition and aldol reaction are among the most basic and commoly used reactions. Cascade halo-Michael/Aldol reaction can effectively improve the atomic economy and step economy of organic synthesis. After the Michael addition of α, β-unsaturated compound with halide ion (Cl^-, Br^-, I^-), the reactive intermediate reacts with aldehyde through aldol reaction in the same reaction system. This process is called cascade halo-Michael/Aldol reaction. The cascade halo-Michael/Aldol reaction and its applications in the synthesis of related compounds according to the types of Lewis acid are introduced.
- halo-michael/aldol reaction,
- cascade reaction,
- Lewis acid,
- application,
- synthesis
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