Citation: Liu Ziqiang, Zhao Ran, He Ni, Li Wei. Trityl Ion-Mediated Oxidative C—H Alkynylation of 1, 2-Dihydroquinolines[J]. Chinese Journal of Organic Chemistry, ;2018, 38(5): 1261-1266. doi: 10.6023/cjoc201803001 shu

Trityl Ion-Mediated Oxidative C—H Alkynylation of 1, 2-Dihydroquinolines

Liu Ziqiang ^a ,
Zhao Ran ^a ,
He Ni ^a ,
Li Wei ^a,,

a.
Department of Pharmaceutical, Shandong University of Traditional Chinese Medicine, Jinan 250355

Corresponding author: Li Wei, liwei6911@163.com
Received Date: 1 March 2018
Revised Date: 16 March 2018
Available Online: 13 May 2018

Figures(1)

An efficient synthesis of α-substituted 1, 2-dihydroquinoline compounds through the oxidative C—H functionalization of N-acyl-dihydroquinoline with diverse organoboron reagents mediated by triphenylcarbium perchlorate (Ph₃CClO₄) is reported. The reaction exhibits good functional group tolerance, allowing for C—H alkynylation and alkenylation proceeding smoothly in good yields.
- dihydroquinoline,
- hydrocarbon functionalization,
- alkynylation,
- carbocation,
- oxidation
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