Citation: Pan Guoshuai, Wu Kongchuan, Deng Zeying, Zhang Xinyu, Zhang Xiaofeng, Lin Shen, Huang Qiufeng. Palladium-Catalyzed C—H Direct Arylation of Uracils and Caffeines with Arenes Using Molecular Oxygen as the Sole Oxidant[J]. Chinese Journal of Organic Chemistry, ;2018, 38(8): 2076-2084. doi: 10.6023/cjoc201802008 shu

Palladium-Catalyzed C—H Direct Arylation of Uracils and Caffeines with Arenes Using Molecular Oxygen as the Sole Oxidant

a.
College of Chemistry & Materials Science, Fujian Normal University, Fuzhou 350007
b.
Key Laboratory of Polymer Materials of Fujian Province, Fuzhou 350007

Corresponding author: Huang Qiufeng, qiufenghuang@fjnu.edu.cn
Received Date: 4 February 2018
Revised Date: 25 March 2018
Available Online: 13 August 2018
Fund Project: the Natural Science Foundation of Fujian Province 2017J01572the National Natural Science Foundation of China 6152010615Project supported by the National Natural Science Foundation of China (No. 6152010615), the Natural Science Foundation of Fujian Province (No. 2017J01572), the Foundation of Fujian Educational Committee (No. JZ160424), the Fujian Province University Fund for New Century Excellent Talents, and Undergraduate Training Program for Innovation and Entrepreneurship (No. 201710394061)the Foundation of Fujian Educational Committee JZ160424the Fujian Province University Fund for New Century Excellent Talents, and Undergraduate Training Program for Innovation and Entrepreneurship 201710394061

Figures(3)

Palladium-catalyzed cross-dehydrogenative coupling of uracil or caffeine with unactivated arenes has been developed. The approach was characterized by using atmospheric pressure of molecular oxygen as the sole oxidant. Functional groups such as halo, ester, nitro, nitrile and ether are well-tolerated under the reaction conditions. This novel strategy provides a straightforward, facile and economical route to C6-aryl uracil derivatives or C8-aryl caffeine derivatives.
- palladium,
- caffeine,
- uracil,
- C—H bond,
- arylation,
- oxygen
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1.
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