Citation: Tan Jiaxi, Guo Ye, Zeng Fei, Chen Guanrong, Xie Longyong, He Weimin. Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Unactivated Carboxylic Acids and Isothiocyanates[J]. Chinese Journal of Organic Chemistry, ;2018, 38(7): 1740-1748. doi: 10.6023/cjoc201801049 shu

Synthesis of Sterically Hindered and Electron-Deficient Secondary Amides from Unactivated Carboxylic Acids and Isothiocyanates

Hunan Provincial Engineering Research Center for Ginkgo biloba, Hunan University of Science and Engineering, Yongzhou 425100

Corresponding author: He Weimin, weiminhe2016@yeah.net
Received Date: 31 January 2018
Revised Date: 18 March 2018
Available Online: 29 July 2018
Fund Project: Innovative Research Team in Higher Educational Institutions of Hunan Province 2012-318the National Natural Science Foundation of China 21302048the National Natural Science Foundation of China 21602055Project supported by the National Natural Science Foundation of China (Nos. 21602055, 21302048), the Science and Technology Innovative Research Team in Higher Educational Institutions of Hunan Province (No. 2012-318) and the Construct Program of the Key Discipline in Hunan Province

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A mild, general and efficient method for the direct synthesis of diverse amides from commercially available carboxylic acids and isothiocyanates has been developed. The strategy does not require stoichiometric amounts of coupling reagents or metal catalysts, and is especially for sterically hindered and electron-deficient secondary amides, which are otherwise challenging to synthesize.
- amides,
- carboxylic acids,
- isothiocyanates,
- synthetic methods,
- electron-deficient amides
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