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Citation: Liu Qinglong, Chen Ahong, Jiang Zhihua, Ma Yanlei, Tang Jinying, Xu Wei, Liu Yanping, Fu Yanhui. A New Indole Alkaloid from the Stems and Leaves of Nauclea officinalis[J]. Chinese Journal of Organic Chemistry, ;2018, 38(7): 1833-1836. doi: 10.6023/cjoc201801042 shu

A New Indole Alkaloid from the Stems and Leaves of Nauclea officinalis

Liu Qinglong ^a,b,c ,
Chen Ahong ^a,b,c ,
Jiang Zhihua ^a,b,c ,
Ma Yanlei ^a,b,c ,
Tang Jinying ^a,b,c ,
Xu Wei ^c ,
Liu Yanping ^a,b,, ,
Fu Yanhui ^a,b,c,,

a.
Key Laboratory of Tropical Medicinal Plant Chemistry of Ministry of Education, Hainan Normal University, Haikou 571158
b.
Key Laboratory of Southern Medicinal Plants Resources of Haikou City, Hainan Normal University, Haikou 571158
c.
College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122

Corresponding author: Liu Yanping, liuyanpinghs@163.com Fu Yanhui, fuyanhui80@163.com
Received Date: 28 January 2018
Revised Date: 17 March 2018
Available Online: 4 July 2018
Fund Project: Project supported by the Applied Technology Research and Development and Demonstration Project of Hainan Province (No. ZDXM2015063), the National Natural Science Foundation of China (Nos. 21662011 and 31660097) and the Program for Innovative Research Team in University (No. IRT-16R19)the Applied Technology Research and Development and Demonstration Project of Hainan Province ZDXM2015063the National Natural Science Foundation of China 31660097the National Natural Science Foundation of China 21662011the Program for Innovative Research Team in University IRT-16R19

Figures(2)

A new indole alkaloid, nauclofficine (1), together with three known alkaloids, naucleamide A (2), naucleamide D (3) and latifoliamide A (4), were isolated from the stems and leaves of Nauclea officinalis. Their structures were established on the basis of extensive spectral analyses. All known compounds were isolated from N. officinalis for the first time. The cytotoxicities of compounds 1~4 were evaluated against five cancer cell lines (HL-60, A549, SMMC-7721, MCF-7 and SW480). Research results showed that compounds 1~4 exhibited significant inhibitory effects with IC₅₀ values comparable to those of cisplatin.
- Nauclea,
- Nauclea officinalis,
- nauclofficine,
- cytotoxicities
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