Citation: Bi Jili, Ma Ransong, Yang Jinhui. Synthesis of Chiral α-Amino Acid Derivatives by Asymmetric Addition of α-Imino Ester[J]. Chinese Journal of Organic Chemistry, ;2018, 38(10): 2553-2570. doi: 10.6023/cjoc201801035 shu

Synthesis of Chiral α-Amino Acid Derivatives by Asymmetric Addition of α-Imino Ester

Bi Jili ^a,, ,
Ma Ransong ^b ,
Yang Jinhui ^c,,

a.
College of Education, Ningxia University, Yinchuan 750021
b.
State Key Laboratory of Applied Organic Chemistry, Lanzhou University, Lanzhou 730000
c.
State Key Laboratory Cultivition Base of Natural Gas Conwersion, Ningxia University, Yinchuan 750021

Corresponding author: Bi Jili, bjlnxdx@126.com Yang Jinhui, yang_jh@nxu.edu.cn
Received Date: 25 January 2018
Revised Date: 2 April 2018
Available Online: 7 October 2018
Fund Project: the National Natural Science Foundation of China 21362025Project supported by the National Natural Science Foundation of China (No. 21362025)

Figures(11)

The wide applications of chiral α-amino acid derivatives in the pharmaceutical and fine chemical industry field has greatly arisen the development of its synthetic methods. So far, asymmetric nucleophilic addition reaction of α-imino ester has been proven to be one of the most effective methods to synthesize chiral α-amino acid derivatives and has been focused by chemists in the field of asymmetric catalysis. The development of such method on the view of reaction types and different kinds of nucleophiles is described. Specifically, allylation reaction, arylation reactions, Mannich reactions, alkenylation reactions, alkynylation reactions and alkylation reactions are introduced, together with the associated reaction mechanisms and recent developments. Additionally, a prospect on this research field is given.
- α-imino ester,
- chiral α-amino acid derivative,
- asymmetric,
- addition reaction References
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