Citation: Liao Shili, Zhang Guogai, Cao Han, Chen Biying, Li Weimin, Wu Xia, Feng Yifan. Synthesis and Anti-tumor Activities against HepG2 Cell in vitro of the Conjugates of Honokiol, Quercetin and Berberine[J]. Chinese Journal of Organic Chemistry, ;2018, 38(6): 1549-1555. doi: 10.6023/cjoc201801023 shu

Synthesis and Anti-tumor Activities against HepG2 Cell in vitro of the Conjugates of Honokiol, Quercetin and Berberine

Liao Shili ^a ,
Zhang Guogai ^a ,
Cao Han ^a ,
Chen Biying ^a ,
Li Weimin ^b,, ,
Wu Xia ^a,, ,
Feng Yifan ^a,,

a.
Central Laboratory, Guangdong Pharmaceutical University, Guangzhou 510000
b.
College of Chinese Materia Medica, Guangzhou University of Chinese Medicine, Guangzhou 510000

Corresponding author: Li Weimin, 13925023915@139.com Wu Xia, wxiaxia@163.com Feng Yifan, yffeng@139.com
Received Date: 26 January 2018
Revised Date: 27 February 2018
Available Online: 8 June 2018
Fund Project: Project supported by the National Natural Science Foundation of China (Nos. 21275036, 81202429)the National Natural Science Foundation of China 81202429the National Natural Science Foundation of China 21275036

Figures(4)

Berberine, honokiol, quercetin are the lead compounds with outstanding anti-tumor activities. Three novel products were synthesized from honokiol, quercetin and berberine. The structures of the products were firstly confirmed by ¹H NMR, ¹³C NMR, 2D NMR, HRMS, IR and UV. All products were evaluated for their anti-tumor activities against HepG2 cell in vitro and the results showed that the inhibitory effects of two compounds on HepG2 cell were far superior to honokiol and berberine hydrochloride, and the anti-tumor activities were similar to the reference drug cisplatin. It means that compounds 1 and 2 are expected to be the potential anti-tumor drugs.
- berberine,
- honokiol,
- quercetin,
- anti-tumor activity
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