Citation: Zhao Wenjiao, Sun Dequn. Novel Drug Development Process of Anti-Alzheimer Targeted to Glycogen Synthase Kinase-3[J]. Chinese Journal of Organic Chemistry, ;2018, 38(7): 1596-1607. doi: 10.6023/cjoc201801022 shu

Novel Drug Development Process of Anti-Alzheimer Targeted to Glycogen Synthase Kinase-3

Zhao Wenjiao ^a,b ,
Sun Dequn ^a,b,,

a.
Marine College, Shandong University at Weihai, Weihai 264209
b.
School of Life Science and Engineering, Southwest University of Science and Technology, Mianyang 621010

Corresponding author: Sun Dequn, dequn.sun@sdu.edu.cn
Received Date: 16 January 2018
Revised Date: 26 March 2018
Available Online: 12 July 2018
Fund Project: Project supported by the National Natural Science Foundation of China (No. 81773560)the National Natural Science Foundation of China 81773560

Figures(16)

Alzheimer's disease is the leading cause of dementia, which can endanger devastating damage to memory and cognition of the elderly and eventually lead to death. Over expression of glycogen synthase kinase-3 (GSK-3) is closely related to the development and progression of Alzheimer's disease, and has become a hot field for the development of therapies for Alzheimer's disease. The GSK-3 inhibitors reported in recent five years, mainly including ATP competitive inhibitors, non-ATP competitive inhibitors, substrate competitive inhibitors, allosteric inhibitors, irreversible inhibitors are summarized and natural products, furthermore, the source, chemical structure and mechanism about GSK-3 inhibitors are introduced. Research prospects in this field are also discussed.
- Alzheimer's disease,
- glycogen synthase kinase-3 (GSK-3),
- amyloid plaque,
- neurofibrillary tangle
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沈阳化工大学材料科学与工程学院沈阳 110142